In this guest blog for Lab Crunches, Shermaine Thein explores the concept of aging and why how old we are may not be as simple as just a number.
Secrets of Aging
This blog was awarded 3rd place in the 2021 Bio-Rad Science Writing Competition.
Gamma Delta T cells: The Unsung Heroes of Immunology
This blog was awarded 2nd place in the 2021 Bio-Rad Science Writing Competition.
Thoughts of Mice: Understanding the Role Serotonin Plays in Cognitive Flexibility
In this blog, we discuss new research that reveals how M. bovis manipulates bovine, but not human, macrophage defenses to cause disease, and helps exp...
Macrophages May Explain Tuberculosis Tropism
The winning submission in the 2021 Bio-Rad Science Writing Competition.
"Fin"tech: Zebrafish Models
Find out who won the 2021 Bio-Rad Science Writing Competition.
2021 Science Writing Competition Results
In this guest blog, we summarize some of the various hypotheses that have been proposed over the years for the development of Alzheimer's diseases, an...
What Causes Alzheimer’s Disease?
This blog gives an overview of the history of the STimulator of Interferon Genes (STING) pathway and highlights why pharmaceutical companies are makin...
The Buzz Around STING Agonists
This blog highlights the threat that canine distemper virus poses to the Amur tiger and discusses whether vaccinating these tigers could help protect ...
Could an Unconventional Vaccine Program Prove a Roaring Success?
This blog highlights the basic principles of spectral flow cytometry and some of its advantages over conventional flow cytometry.
An Introduction to Spectral Flow Cytometry
AKT is an extremely important kinase in human health, playing an intricate role in coordinating fundamental signaling pathways. This blog discusses a ...
A Balancing AKT: the E17K Hotspot Mutation and How It Defines Cancer
This guest blog discusses impostor syndrome in graduate school and practical steps you can take to combat these feelings.
Impostor Syndrome: Being a Graduate Student in the Sciences
In this guest blog, Christine Lalonde, a Postdoctoral Fellow at Laurentian University, Canada, shares her experience of a multidisciplinary research c...
Big Dreams: Multidisciplinary Science — Not a Fairytale
This blog discusses a paper published in Cell Host and Microbe by Bruggisser et al. (2020) that shows that CD31 is crucial for C. perfringens pathogen...
Unlocking the Mechanism of a Deadly Infection in Pigs
In this guest blog, Priyankaa Pitcheshwar, a PhD student working in the area of adenosine-to-inosine (A-to-I) RNA editing in the context of cancer, te...
The Transcriptomic Swiss Army Knife— A-to-I RNA Editing
This guest blog takes a look at pattern recognition receptors and how they mount an immune response against viruses.
How Do Pattern Recognition Receptors Help Mount an Immune Response?
Design robust experiments and troubleshoot existing protocols for measuring apoptosis by flow cytometry, by following the advice in this blog.
How to Use Flow Cytometry to Measure Apoptosis: Part Two
Guest contributor, Marta González-Prieto shares her love story with her PhD project and how despite initial challenges they eventually got the happy e...
My PhD Love Affair
This guest blog examines a paper published by Caddy et al. (2020) in EMBO Journal that sheds new light on anti-nucleoprotein antibodies and clearance ...
Looking Beneath the Surface: Viral Clearance by Anti-Nucleoproteins
As part of International Day of Women and Girls in Science, Bio-Rad invited researchers to share their own experiences of being a women in science. In...
Voices of Women in Science: Assistant Professor Lynda Coughlan
Voices of Women in Science: Professor Sara Mole
As part of International Day of Women and Girls in Science, Bio-Rad invited researchers to share their own experiences of being a women in science. In...
Voices of Women in Science: Olivia Blondheim
Learn about the different tools for studying apoptosis by flow cytometry and how to use them to get the best results.
How to Use Flow Cytometry to Measure Apoptosis: Part One
Can T cells influence our brain function? In this guest blog, we explore the contribution of T cells to learning and memory.
A T Cell for Your Thoughts?
In this guest blog, Emma Green tells us why the value of a PhD is more than just your research and what she learned from the experience.
The PhD: More than a Thesis
This blog discusses the CRISPR technology that was awarded the 2020 Nobel Prize in Chemistry.
How CRISPR Revolutionized Science
Bio-Rad has searched through our catalog to show you some of our antibodies with hilarious names from Pokemon to dinosaurs.
Pokemon Antibody - I Choose You
In this guest blog, we take a look at some of the areas outside of allergy that mast cells play a role in.
A MASTer Immune cell
Guest contributor Zill-e-Anam Shares her tips for staying on track when you have to switch PhD project, for reasons outside of your control.
Tips to Help You Succeed When You Have to Switch PhD Project
In this blog, we will explain what alamarBlue is and how it works, and then explore three main benefits of this reagent.
3 Reasons to Use alamarBlue In Your Cell Proliferation Studies
In this guest blog, Sabine shares the research challenges caused by the pandemic and how her lab has implemented small changes to how they work for th...
Lessons from the Pandemic: How to Be a Good Lab Mate
This blog will take you through the basics of IP so you can get successful results from the outset.
How to Pull-Down Your Target Protein and Interactors Successfully
In this guest blog, we discuss ghost tangles, the remains of tau (found after neuronal death), and their effects.
Secrets of the Haunted Brain: Ghost Tangles
In this guest blog, Emma Green discusses why cell replacement therapy may offer hope for restoring movement in people with Parkinson's Disease.
Hopes to Restore Movement in People with Parkinson’s
In this blog, guest contributor Shermaine Thein shares some of the insights that she has learned about aging as a graduate student stepping into the r...
An Age Old Question
This blog describes the forces that cells undergo during sorting, and practical steps you can take to minimize cell stress and get great results in yo...
How to Avoid Cell Stress While Cell Sorting
In this blog, we examine why understanding the oxygen sensing mechanisms of cells was worthy of a Nobel Prize and interview Professor Sir Peter Ratcli...
The Path to a Nobel Prize
In this blog, Guest Writer Samantha Zambuto shares her perspective on why it is important that scientists study women’s health.
Performing Inclusive Research in the Lab
This blog takes a look at the career of June Almeida, who became a pioneer in the imaging and identification of viruses.
Seeing SARS – the Remarkable Story of June Almeida
This article was awarded 3rd place in the 2020 Bio-Rad Science Writing Competition.
Slash the Tires Instead to Slow Down Prostate Cancer
This article was awarded 2nd place in the 2020 Bio-Rad Science Writing Competition.
Out of My Comfort Zone: How I Use Science to Influence Policy
This blog discusses the CCR5 co-receptor and the role that it could play in an HIV cure, as well as the patients who appear to be in long-term remissi...
Is a Cure for HIV on the Horizon?
This blog discusses the reasons why non-animal derived recombinant antibodies are something that both antibody suppliers and researchers should consid...
Making the Switch to Non-Animal Derived Antibodies
The winners of the 2020 Bio-Rad Science Writing Competition are revealed.
Science Writing Competition Results
Read the winning article of the 2020 Bio-Rad Science Writing Competition by Alex Du Feu.
Inspiring Science - Why Public Engagement Is Key
In this blog, we discuss the potential for a monoclonal antibody to neutralize the SARS-CoV-2 virus that causes COVID-19.
Could a Monoclonal Antibody Cure COVID-19?
In this blog, our Flow Cytometry Research Associate shares 9 top tips to generate publication-worthy flow plots in a format that reviewers would like ...
9 Tips to Get Publication Ready Flow Plots
Sometimes our immune systems launch an excessive, disproportionate response to a real infection, called a "cytokine storm". This blog looks at cytokin...
Navigating the Deadly Cytokine Storm
This blog post focuses on BrdU and top tips and tricks for conducting a BrdU labeling experiment to help you troubleshoot any BrdU blues.
Top Tips for Troubleshooting Your BrdU Blues
This blog contains our top tips to help you be more organized and do the best possible science.
4 Ways to Organize Your Way to Better Science
In the wake of the SARS-CoV2 pandemic, social distancing has meant that labs all over the world have needed to temporarily shut. Read our blog on 9 th...
Keeping Distance from the Lab: 9 Ways to Be Productive
Stuart Weston PhD, coronavirologist, shares his insights on what it is like being a researcher in coronaviruses during the 2020 pandemic.
Diary of a Coronavirologist
International Women’s Day is celebrated on 8th March all over the world to highlight the many achievements of women. To mark the occasion, in this blo...
Three Remarkable Women Who Shaped the Antibody Field
This blog tells the story of rapamycin’s discovery, identification of the mTOR signaling pathway, and highlights the important role that basic researc...
The HisTORy behind the Discovery of Rapamycin
This blog is written to help you perfect your IHC-paraffin technique. It focuses on some of the key stages so that you can achieve publication-qualit...
A Guide to IHC-paraffin Success
Bio-Rad's Flow Cytometry Research Associate, Sharon shares her experience of transitioning from academic research to working in an industry setting in...
The Transition from Academia to Industry
2020 is the start of a new decade. Take inspiration from other scientists and set yourself goals for the year ahead.
New Year's Lab Resolutions
Discover the most festive offerings in our portfolios and their associated “Festive Factor” scores.
Have you got the Festive Factor?
In this podcast, we explain what International Non-proprietary Names are, and the logic behind their use.
Podcast: The Logic Behind Biologic Antibody Drug Names
In this blog, we take a look at sandwich and competitive ELISAs and highlight some of our top ELISA tips.
ELISAs Do Little? Your Guide to ELISAs Part Two
Enzyme-Linked Immunosorbent Assays (ELISAs) are widely used for the detection and quantification of proteins, peptides, hormones, and other substances...
ELISAs Do Little? Your Guide to ELISAs Part One
This blog discusses phosphorylation, a common regulator of signal transduction pathways and the role of inappropriate phosphorylation events in cancer...
The Importance of Phosphorylation Events in Cancer
In this guest blog, Dr Elisa Vitiello shares her tips on making the transition from being a PhD student to getting your first job in academic research...
How to Successfully Manage the PhD-to-Postdoc Transition
This blog takes a look at the logic behind the names of monoclonal antibody drugs and implications of the more recent changes in the naming structure....
WHO Decides What’s INN a Biologics Name?
This blog examines new findings that suggest the brain is far more resilient than we have assumed, and that challenge the idea that some functions are...
Pig Brains and the Gray Matter of Life and Death
This blog discusses the three basic types of controls that should be included in a western blot experiment and provides a good starting point for trou...
Taking Control of Your Western Blotting Troubles
In this podcast, Bio-Rad reviews three popular methods for studying cell proliferation: using thymidine analogs, quantifying DNA content, and detectin...
Podcast: Studying Cell Proliferation
In this podcast, you will learn how to use the different types of viability dyes and exclude dead cells from flow cytometry assays.
Podcast: Viability Dyes and How to Exclude Dead Cells from Your Analysis
In this podcast, learn how to prepare blood samples ready for flow cytometry experiments with Bio-Rad’s top three tips.
Podcast: Sample Preparation Tips for Blood Samples
This blog discusses a recent study by Bohn et al. (2018) that highlights a mechanism that melanoma utilizes to subvert the immune response.
Tumors Sweet Success due to Macrophage Polarization
This blog highlights how A.I technology is being used to shape scientific discoveries and research direction.
A.dvancI.ng Scientific Research
Learn how you can optimize your conditions to improve detection of rare populations by flow cytometry in this podcast from Bio-Rad.
Podcast: The Importance of Cell Frequency
Krishnamoorthy et al. (2018) have identified enucleated neutrophil cell bodies, known as ‘ghosts’, as driving Th17 cell inflammation in severe asthma....
Manifestation of Ghosts Exacerbates Asthma
The 2018 Nobel Prize announcements brought exciting news of two prizes awarded in recognition of ground-breaking achievements in the antibody field.
NEWS: Nobel Prizes for the Antibody Field
This blog focuses on gastrointestinal organoids and their role in advancing cancer research and therapy.
Can Medicine Trust Your Gut Organoids?
Listen to Bio-Rad’s top tips for studying SUMOylation in our podcast.
Podcast: Studying SUMOylation
Learn Bio-Rad’s practical tips for controlling your BrdU experiments in our podcast.
Podcast: BrdU in Adult Neurogenesis Research
This blog features some of our top sample preparation tips for flow cytometry and examples of blood and tumor sample preparation.
Set Yourself up for Success with Flow Cytometry
This blog takes a look at how gut microbiota may play a role in anti-tumor immune responses.
The Good, the Bad and the Ugly Side of the Gut Microbiome
Learn more about a groundbreaking discovery in Babraham pigs that has significantly improved its usefulness as an immunological model.
Pigging up the Pace of Influenza A Vaccine Development
This blog discusses the PD-1 (programmed cell death-1) pathway and two licensed immunotherapy drugs that target it, pembrolizumab and nivolumab.
Checkmate: Beating Cancer through the PD-1 Pathway
Th2A cells are a recently identified subset of T helper cells type 2 (Th2). This blog looks at the role of Th2A cells in allergy.
Th2A Cells — the Latest T Helper Cell Subset and its Role in Allergy
This blog discusses therapeutic drug monitoring and why it is used for conditions such as IBD to ensure that treatment remains safe and effective.
Getting the Dose Right
Baranska et al. (2018) identify macrophage dynamics as being key to tattoos lasting. This blog examines why tattoos are so difficult to remove.
Inking the Immune System: How Macrophages Make Tattoos Last
Learn how to build better panels for flow cytometry through optimizing for antigen density, using a dump channel and including viability markers.
How to Get More Out of Your Multicolor Panels
We examine SUMOylation, the effect of their aberrant SUMOylation on signaling pathways and the potential of SUMO inhibitors in cancer therapy.
SUMOylation: a Heavyweight in the Regulation of Cell Cycle Progression and Cell Proliferation – Part Two
This blog post discusses the discovery of SUMO and the importance of SUMOylation in cell cycle regulation and cellular proliferation.
SUMOylation: a Heavyweight in the Regulation of Cell Cycle Progression and Cell Proliferation – Part One
We examine the history of Epidermal growth factor receptor (EGF R), the EGF R family and function along with how EGF R promotes cancer development.
Why EGF R is an Attractive Target for Cancer Therapy
This blog describes scientific findings describing the mechanism behind the failure of beta cells to proliferate in patients with type 2 diabetes
The underlying reason beta cells fail to proliferate in “diabesity” uncovered
Discover new studies describing the auto-immune mechanism associated with the development of Parkinson's Disease.
The possible autoimmune nature of Parkinson’s disease
This blog describes studies demonstrating the beneficial role of commensal bacteria in treating microbial infections and antibiotic resistance.
How good bacteria protect us from pathogenic infection
Discover the features of rats that make them ideal animal models for scientific research and new discoveries generated using transgenic rat models.
Rats — An ideal animal model of human disease
Learn how a new tool from Bio-Rad simplifies knowing what markers to use to identify certain immune cell types.
How to identify major immune cell types by their CD marker expression
Our second part of BrdU in adult neurogenesis research, describes “the dark side of BrdU” and how you can carefully control BrdU labeling experiments...
Bromodeoxyuridine (BrdU) in adult neurogenesis research - Part 2
The first of a two part series describing how BrdU revolutionized the field of neurogenesis.
Bromodeoxyuridine (BrdU) in adult neurogenesis research - Part 1
This blog post describes the mechanisms by which macrophages induce insulin resistance in the obese state.
Macrophages, obesity and insulin resistance
This post describes the role of monocytes in heart disease and whether monocyte infiltration into the heart exacerbates disease or aids in its repair....
What do monocytes have to do with the heart?
This blog post highlights major research findings on ZIKV in 2016, and provides a perspective on how scientists addressed this public health issue.
The rise in Zika virus research — an update
We are excited to share that Bio-Rad was named as the CiteAb Custom Antibody Supplier of the year.
Bio-Rad named CiteAb Custom Antibody Supplier of the year!
This blog post will take you through the various gating strategies for effective flow cytometry analysis.
A guide to gating in flow cytometry
Fluorescent proteins have expanded the capabilities of scientists, thus allowing observations that would not have been possible without them.
Illuminating biomedical research — the story of fluorescent proteins
Researchers partnered with Bio-Rad to engineer high affinity, highly specific inhibitor antibodies to the active site region of a WNV proteinase.
Engineering recombinant inhibitory antibodies as research tools
This blog post highlights autophagy as a therapeutic strategy for neurodegeneration.
Autophagy, and Neurodegeneration
While insects are not the deadliest animals they can significantly impact human health. Learn about the killer bug and Asian giant hornet.
Killer bugs among us - the kissing bug and the Asian giant hornet
In this blog post we highlight some the current potholes on the road to reproducible antibodies.
The road to antibody validation standards
This blog post defines critical reagents and best practices for their characterization.
Applying best practices for characterizing critical reagents
We describe the different types of ELISAs, the advantages and disadvantages of each and what to consider before choosing an ELISA technique.
Deciding which ELISA technique is right for you
This blog post highlights the key ubiquitin E3 ligases currently considered molecular drug targets.
When ubiquitination goes bad, knock it out for effective cancer therapy
Learn more about the biology of the transmissible canine cancer CTVT and why it is a biological curiosity of significant magnitude in this blog post.
The oldest known naturally occurring cancer is transmitted between dogs
This blog post discusses recent pre-clinical studies that suggest monocytes could be applied in a related manner to the treatment of diseases.
Monocyte-based cell therapy for treating diseases
This blog describes the triggers & mechanisms that lead to death by apoptosis, as well as assays for measuring apoptosis in your research.
Cell death by apoptosis - the journey of a single cell from health to death
Within the immune response to cancer macrophages present both a problem and solution. This post describes how they can assist with tumor clearance.
Inducing macrophages that work against rather than for cancer
This blog post highlights novel gene-editing strategies to protect pigs against dangerous pathogens.
The science of keeping pigs healthy
HuCAL technology was used to develop high specificity, high affinity antibodies to distinguish between protein isoforms with only minor differences.
Biomarker assay development: CXCL10 in HCV infection
In this blog post we simplify the Flow Cytometry process in five easy steps that will ensure successful results.
5 Easy Steps for Successful Flow Cytometry
The GATA family of transcription factors is emerging as key players in establishing new biomarkers for rapid and accurate detection of cancer. Find ou...
GATA transcription factors and their role in cancer diagnosis and prognosis
The new finding of trained immunity challenges the basic tenets of immunology, blurring the line that separates innate and adaptive immunity.
Immunological memory is no longer a unique trait of adaptive immune cells
In this blog post, we describe the history, epidemiology and biology of the Zika virus.
Zika virus — a new viral threat for 2016?
This blog post provides insight on how to improve your assay sensitivity by selecting antibodies based on binding strength as well as affinity.
High affinity antibodies for improved analysis of antibody drugs
Join us as we take a walk down memory lane and tell the story of how monoclonal antibodies for research purposes came to be.
Journey to the antibody vial: the story of monoclonal antibodies in research
This blog post discusses TidyBlot and how it does not detect IgG heavy and light chains in your co-IP experiment.
How to detect your target protein or protein complex without interfering IgG chains
This blog post provides an update on the current Ebola epidemic, citing evidence that the virus can linger in immune privileged sites inside the body....
Does the Ebola virus ever really go away?
With over 35 years of experience with antibodies, we offer our expert advice for taking care of your antibodies for consistent results.
“Is it the antibody?” Tips for caring for your antibody for consistent results
"There has been a paradigm shift in how the treatment of diseases is approached." This post describes how genome sequencing is revolutionizing the tre...
Tailor-made just for you: A future with precision medicine
This blog post describes the applicability of recombinant antibody fragments from a naive antibody library for immuno-MRM based quantification.
Immuno-MRM analyses: high-affinity recombinant antibody fragments
This blog post describes the current efforts and streams of thought for generating antibody validation standards to address the scientific reproducibi...
Standardizing Antibody Validation
This blog post describes how your choice of cooking method may increase your risk for developing a range of diseases, including Alzheimer's
Are you likely to develop Alzheimer’s from grilled food?
This post describes how natural phosphatase inhibitors impact on human health.
Natural phosphatase inhibitors: the danger around us
This post describes crucial markers and useful markers to study aberrant cell proliferation.
Measuring the inevitable divide - tools for assessing cell proliferation
This post describes what tandem dyes are and what to keep in mind when incorporating them into your flow cytometry panels.
Tandem dyes - The power couples of Flow Cytometry
This post describes how mutations in proto-oncogenes and tumor suppressor genes account for tumorigenesis.
Inheriting mutant tumor suppressor genes increases your risk for cancer
This post describes what an isotype control is and how one could be beneficial in your multi-color flow cytometry experiments.
To control or not to control, that is the multi-color flow question…
This post describes selecting fluorophores for your IF experiments based on dye characteristics, such as quantum yields and extinction coefficients.
Light up your IF experiments with our continued tips and tricks
This post describes how to choose fluorophores for IF experiments based on dye characteristics, such as quantum yields and extinction coefficients.
Take a quantum leap in your IF experiments with our 5 tips and tricks
Have a group of researchers really found the key to a cure to the currently incurable Dengue virus? Find out here...
Four virus serotypes…One Dengue vaccine?
This post describes a few key factors to consider when designing intracellular flow cytometry experiments.
Intracellular flow cytometry - the good, the bad and the cytokines
This post provides flow cytometry novices with a basic overview of how to design a multi-color flow cytometry panel.
10 tips for designing a basic flow cytometry panel
6 Tips to Secure Funding for Flow Cytometers
[POSTER] PI3K/AKT Signaling Pathway
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