Cancer antibodies, proteins, and reagents for cancer research

Melanoma research

Antibodies for the analysis of melanoma onset and development

SnapShot from Cell Press: Melanoma poster

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The “SnapShot from Cell Press: Melanoma” poster describes the most common mutations resulting in melanomas and disease progression as well as cell signaling cascades frequently altered in this disease. These include the PI3-Kinase/AKT and the MAPK/ERK mediated signaling pathways. Aberrant regulation of the latter is most commonly triggered by constitutive BRAF kinase activity caused by a mutation of valine residue 600 to glutamic acid (BRAF (V600E)). Other regular triggers of melanoma development include mutations in the NRAS proto-oncogene and the TP53, PTEN tumor suppressor genes. Mutations in CD117/KIT have also been reported, although at a much lower frequency. For a complete overview of the frequency of the common mutations and deletions resulting in melanoma, download or request the melanoma poster.

In order to make it easier for you to select reagents for melanoma research, we have grouped antibodies against the critical proteins mentioned on the poster together in a convenient selector tool. These include our range of p53 antibodies, mTOR and MEK1 PrecisionAb™ Western blot validated antibodies. Each PrecisionAb product has been carefully selected after comprehensive performance testing in up to twelve different whole cell lysates. PrecisionAb products are characterized by their high specificity, high sensitivity and batch to batch consistency (every antibody lot has to meet the same strict quality control criteria). For more information, check our PrecisionAb range.


Antibodies for Melanoma Research

Melanoma

AKT1
BAX
Cdk4
ERK1
mTOR
PI-3 Kinase
TRAF2
AKT2
BIM
CYCLIN D1
H-Ras
NFkB
PTEN
WT1
ARAF
CATENIN BETA
EGF R
MDM2
p21/WAF1
RAC2
BAD
CD117/KIT
ERK/MAPK
MEK 1
p53
RAF-1

Melanoma p53 Signaling Panel

Target

Clone

Applications

Catalog Number

p53

D0-1

FC, IHC- P, WB, IP, E

MCA1701 

p53

DO-7

FC, IHC- P, WB, IP, E

MCA1703 

p53

DO-11

FC, IHC- P, WB, IP

MCA1704 

p53 pSer15

Polyclonal

WB

AHP2339

p53 pSer392

Polyclonal

WB

AHP906

p53 pSer392

FP3-2

WB, IHC-P , IP

MCA1842

mTOR

Polyclonal

WB

AHP2498

Beta-catenin

Polyclonal

WB

AHP2418

MDM2

1A7

IHC-P, WB

MCA3255Z

iASSP

Polyclonal

WB, E

AHP1338

Melanoma Treatment Resistance Panel

Target

Clone

Applications

Catalog Number

PTEN

A2b1

IHC-F, WB, IP

OBT1120

Cyclin D1

Polyclonal

WB, E

2407-0508 

Cyclin D1

CD1.1

IHC, WB, F, IP, E

MCA1756

CDK4

DCS-31.2

IHC-F, WM, IP

MCA1994 

CDK4

Polyclonal

IHC-P, WB

AHP2454

CDK6

DCs-83.1

IHC-F, IP , WB

MCA1992 

CDK6

Polyclonal

IHC-P, WB

AHP2455 

c-Met

4AT44

WB, E

OBT2042 

IHC Melanoma Diagnostic Markers

Target

Clone

Applications

Catalog Number

HMB45/Pmel/SILV/gp100

HMB45

IHC-F, IHC-P

MCA2146

Melan-A

M2-7C10

IHC-P

MCA2207

Melan-A

A103

IHC-P, IHC-F, WB

MCA2083

Tyrosinase

2A2-F4

IHC-P, WB

MCA4186Z

s100 proteins

Polyclonal

IHC-F, IHC-P

AHP385

Abbreviations: 
E, ELISA; FC, flow cytometry; IHC-F, immunohistochemistry - frozen; IHC-P, immunohistochemistry - paraffin; IP, immunoprecipitation; WB, western blotting.

Antibodies for Melanoma

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code