Innate immunity is the front line, non-specific and immediate response to pathogens and to the unrecognized self. As a part of the larger immune system, innate immunity comprises a variety of molecules, cell types and signaling cascades which typically do not adapt to previous infection or vaccination.
The innate immune system mediates its response to infection by several means including: direct pathogen destruction, identification and clearance of foreign substances, recruitment of immune mediators by biochemical signaling and stimulation of the adaptive immune response.
Bio-Rad provides an extensive collection of antibodies, reagents, controls and standards for innate immunity research.
Range of macrophage, monocyte & dendritic cell markers against target species including human, mouse and rat
Antibodies to key traditional markers such as CD16 and CD56 in humans, and CD161 in the mouse plus more recently discovered markers for signaling and effector molecules
Continually developing range of antibodies and recombinant proteins covering pivotal components of the complement cascade
Wide variety of antibodies to the main types of PRRs; Toll-like receptors (TLR), C-type lectin receptors (CLR), RIG-I-like receptors (RLR) and NOD-like receptors (NLR)
Range of antibodies to mouse and human TLRs including those involved in the TLR signaling cascade & TLRs expressed on adaptive immune cells such as B cells
Range of antibodies and recombinant proteins to cytokines and chemokines, and their associated receptors
Functional review, markers and antibodies to the four types of granulocyte; basophils, eosinophils, neutrophils and mast cells
ILC development, function and subset characterization of ILC1, ILC2 and ILC3; including key ILC markers and antibodies
Role and interplay between commensal microbiota, microvillus and resident immune cells.