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Antibodies for researching proteins frequently altered in AML
SnapShot from Cell Press: Acute Myeloid Leukemia poster
The “SnapShot from Cell Press: Acute Myeloid Leukemia” poster describes the most common gene mutations underlying Acute Myeloid Leukemia (AML). These include mutations in genes encoding cell signaling proteins such as the PTEN phosphatase and the CD135/FLT3 and CD117/KIT receptor tyrosine kinases. Mutations in transcription factors, such as p53 and NPM1, and in epigenetic modifiers, such as the DNA methyltransferase DNMT3A, have also been reported. For a complete overview of the frequency of common gene mutations, AML risk stratifications and current therapies, download or request the AML poster.
In order to make it easier for you to select reagents for AML research, we have grouped antibodies against the critical proteins mentioned on the poster together in a convenient selector tool. These include our range of p53 antibodies, mTOR and MEK1 PrecisionAb™ Western blot validated antibodies. Each PrecisionAb product has been carefully selected after comprehensive performance testing in up to twelve different whole cell lysates. PrecisionAb products are characterized by their high specificity, high sensitivity and batch to batch consistency (every antibody lot has to meet the same strict quality control criteria). For more information, check our PrecisionAb range.