Cyclin D1 antibody | RM241

Rabbit anti Cyclin D1

Product Type
Monoclonal Antibody
Clone
RM241
Isotype
IgG
Specificity
Cyclin D1

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MCA6301
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Rabbit anti Human cyclin D1 antibody, clone RM241 recognizes G1/S-specific cyclin-D1, also known as CCND1, BCL1, PRAD1. Cyclins are protein kinases required for cell cycle progression, and different cyclins execute their functions at different stages of the cell cycle by binding to cyclin-dependent kinases (CDKs). Through its interaction with CDK4 and CDK6, cyclin D1 plays the essential role of promoting G1 to S phase transition (Alao 2007). The gene encoding cyclin D1, CCND1, is a human oncogene, and is overexpressed in up to 50% of human breast cancers (Casimiro et al.. 2015). Overexpression of CCND1 leads to dysregulated CDK activity, rapid cell growth, bypass of cell cycle checkpoints, and neoplastic growth (Qie and Diehl. 2016).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Bovine Expected from Sequence
Mouse Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography of Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to cyclin D1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/500 1/1000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Synonyms
G1/S-specific cyclin-D1
UniProt
P24385
Entrez Gene
CCND1
GO Terms
GO:0000080 G1 phase of mitotic cell cycle
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000084 S phase of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0001934 positive regulation of protein phosphorylation
GO:0005829 cytosol
GO:0005654 nucleoplasm
GO:0042493 response to drug
GO:0019901 protein kinase binding
GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
GO:0045737 positive regulation of cyclin-dependent protein kinase activity
GO:0051301 cell division
GO:0070141 response to UV-A
View more products with CYCLIN D1 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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