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Fig1. Quality check by size exclusion chromatography of recombinant human IgG2/kappa
Selecting an appropriate isotype control is crucial in the antibody drug discovery process, as well as for certain diagnostic assays involving human antibodies.
Isotype controls are used as negative controls to differentiate the non-specific background signals initiated by the antibody Fc backbone or other cellular protein interactions, from the target-specific antibody signal.
Fig2. Quality check of recombinant human IgG2/kappa by SDS-PAGE
The ideal negative controls:
We offer the most comprehensive list of fully-human recombinant immunoglobulin monoclonal antibodies for use as negative controls in preclinical and in vitro studies.
The recombinant nature ensures the continuity of supply and consistent performance needed for antibodies used in effective clinical trial assay development.