Antibodies to YTE Mutations

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Antibodies for Bioanalysis and Drug Monitoring of Drugs Containing YTE Mutations

Develop highly selective and sensitive PK assays for antibody drugs containing YTE mutations in the Fc region using our range of ready-made antibodies.

• Sequence defined, well characterized reagents with secure supply
• Recombinant production, stringent quality control for batch-to-batch consistency
• Non-animal-derived antibodies, reducing the use of animals in science

Table 1. Antibodies specific to YTE mutations.

* Affinity measured in the monovalent Fab format.
¹ Fab-F-Spy2-H = Monovalent Fab antibody with (F) DYKDDDDK, (Spy2) SpyTag version 2, and (H) His-6-tags.
² Fab2-FH-X22-HRP = Bivalent Fab antibody with (F) DYKDDDDK, (H) His-6-tags, and Fab-SpyTag coupled to HRP-conjugated BiCatcher.

Antibodies Specific to YTE Mutations 

Biotherapeutics containing YTE mutations incorporate the M252Y, S254T, and T256E (YTE) triple substitution in the Fc region, a modification shown to extend antibody half-life compared with wild-type IgG. Anti-YTE antibodies specifically recognize YTE mutations enabling selective detection of YTE-modified therapeutics. These antibodies are ideal for the development of pharmacokinetic (PK) bridging ELISAs to measure free drug.

ELISA Protocols to Get You Started

PK Bridging ELISA

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Resources

Licensed Use: For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.