Cell proliferation, motility, and survival are tightly regulated by a network of signaling pathways, preventing uncontrolled cell division. A cell can become cancerous when it undergoes a genetic or epigenetic mutation that allows it to escape this regulation and can then divide rapidly. Unraveling the complex fabric of signaling pathways is crucial for cancer research, and for developing new, life-changing therapies for patients.

The signaling pathway posters highlighted here integrate the latest discoveries in the field and related Bio-Rad antibodies.

EGF R Signaling

EGF R Signaling and kits

ErbB family members are instrumental in the development and malignancy of various human cancers. Deregulation in signaling networks can be caused by kinase mutations and/or overexpression of the receptor. A better understanding of the precise roles of the various EGF R-mediated signaling pathways is crucial for translating these findings into new cancer therapies. We have compiled key proteins involved in the EGF R signaling pathway into one handy poster.
 

mTOR Signaling

mTOR signaling

Understanding mTOR signaling provides a basis for developing mTOR inhibitors, and inhibitors of components within the wider signaling pathway. Inhibition of the mTOR pathway is relevant for cancer, obesity, diabetes, and even aging. Uncover the proteins involved.

NF-kB Signaling

NF-kB Signaling

Nuclear Factor-Kappa B is a transcription factor responsible for generating the protective inflammatory response following infection or injury. However, constitutive activation of NF-κB leads to chronic diseases and inflammatory disorders, and promotes cancer progression. Understanding the balance between the roles of NF-κB in cell health and disease is fundamental in the development of targeted inhibitors of inflammation. Uncover the proteins involved.

Acute Myeloid Leukemia: SnapShot from Cell Press

Acute Myeloid Leukemia: SnapShot from Cell Press An overview of acute myeloid leukemia (AML) risk stratifications, frequency, and types of genetic alterations, as well as current therapies.

Melanoma: SnapShot from Cell Press

Melanoma: SnapShot from Cell Press Covers the most common genetic mutations resulting in the development of melanomas, highlights the progression from an aberrant melanocyte to a metastatic melanoma and treatment approaches.

Mitochondrial Dynamicsa: SnapShot from Cell Press

Mitochondrial Dynamicsa: SnapShot from Cell Press An overview of the mitochondrial fusion-division cycle, and the fusion and division machinery in mammalian cells, yeast, and algae.