Optimize your assays using recombinant antibodies selected for desired affinity
Custom and ready-made anti-drug antibodies to support the generation of biotherapeutics in preclinical research and clinical development
High affinity, fully human anti-drug antibodies are perfect for use in Pharmacokinetic (PK) and Immune Response (IR) assays and reduce the time and effort needed for assay development.
Select an antibody from our wide-range of ready-made anti-drug antibodies, or opt for our custom service and generate an antibody specific for your requirements.
The Human Combinatorial Antibody Library (HuCAL®) technology supports efficient therapeutic drug development:
Figure 1: Anti-idiotypic antibody (blue) used in a bridging format in an immune response assay
- Selection on drug in the presence of blockers for paratope specificity
- Selection in the presence of human serum for avoidance of matrix effects
- Isolation of rare specificities such as drug-target complex binders
More information about generation of anti-drug antibodies using HuCAL technology
How to improve your antibody drug development assays with anti-idiotypic antibodies.
Find out how recombinant monoclonal anti-idiotypic antibodies are generated at Bio-Rad, and how they can be used to develop highly specific and sensitive PK and ADA assays.
Our ready-made anti-biotherapeutic antibodies are supported with data for PK, IR and inhibition assays. They are available in monovalent Fab and IgG1 formats and have sensitivity in the low ng/ml range in 10% human serum, using a standard ELISA bridging format.
More information about anti-biotherapeutic antibodies for preclinical research and clinical development
HuCAL® is a registered trademark of MorphoSys AG.