Anti-drug Antibodies

Custom and ready-made anti-drug antibodies to support the generation of biotherapeutics in preclinical research and clinical development

High affinity, fully human anti-drug antibodies are perfect for use in Pharmacokinetic (PK) and Immune Response (IR) assays and reduce the time and effort needed for assay development.

Select an antibody from our wide-range of ready-made anti-drug antibodies, or opt for our custom service and generate an antibody specific for your requirements.

  • In vitro technology, no immunization of animals
  • Guided selection strategies for challenging specificities
  • Established, proven and published technology
  • Secure and unlimited supply
  • Greater than 90% success rates

 

Figure 1: Anti-idiotypic antibody (blue) used in a bridging format in an immune response assay

Figure 1: Anti-idiotypic antibody (blue) used in a bridging format in an immune response assay

HuCAL® Custom Monoclonal Anti-Drug Antibody (ADA) Generation

The Human Combinatorial Antibody Library (HuCAL®) technology supports efficient therapeutic drug development:

  • Highly specific, fully human anti-idiotypic Fab antibodies in 8 weeks
  • Guided selection strategies:

- Selection on drug in the presence of blockers for paratope specificity
- Selection in the presence of human serum for avoidance of matrix effects
- Isolation of rare specificities such as drug-target complex binders

  • Conversion to fully human immunoglobulins for use as reference standards IgA, IgE, IgG1, IgG2, IgG3, IgG4, IgM
  • Optional screening for inhibiting or neutralizing antibodies
  • Unlimited supply, eliminates the need for revalidation of new sources in extensive clinical studies

More information about generation of anti-drug antibodies using HuCAL technology


Effective Tools for Drug monitoring Assays

Watch our webinar

How to improve your antibody drug development assays with anti-idiotypic antibodies.

Find out how recombinant monoclonal anti-idiotypic antibodies are generated at Bio-Rad, and how they can be used to develop highly specific and sensitive PK and ADA assays.


Antibodies to Biotherapeutics

Our ready-made anti-biotherapeutic antibodies are supported with data for PK, IR and inhibition assays. They are available in monovalent Fab and IgG1 formats and have sensitivity in the low ng/ml range in 10% human serum, using a standard ELISA bridging format.

More information about anti-biotherapeutic antibodies for preclinical research and clinical development

Anti-Biotherapeutic Antibody Range

  Supporting Data
Antigen PK/PD IR Inhibition
Adalimumab Yes Yes Yes
Alemtuzumab Yes Yes Yes
Bevacizumab Yes Yes  
Cetuximab Yes Yes Yes
Golimumab  Yes Yes Yes
Infliximab Yes Yes Yes
Natalizumab  Yes Yes Yes
Omalizumab Yes Yes Yes
Palivizumab Yes Yes  
Panitumumab Yes Yes Yes
Rituximab Yes Yes  
Tocilizumab Yes Yes Yes
Trastuzumab Yes Yes Yes
Ustekinumab Yes Yes Yes

HuCAL® is a registered trademark of MorphoSys AG.