Rapid Custom Antibody Generation for SARS-CoV-2 Assay Development

Reduce Lead Time for Antibody Generation

Assays supporting SARS-CoV-2 vaccine, therapeutic, and diagnostic test development must be robust, scalable, and transferable to laboratories worldwide. They need to be designed and validated rapidly, yet without compromising quality.

We understand that critical antibody reagents for these vital assays must be highly specific for the chosen antigen, produced to a consistent quality, and easily available for scale-up according to demand. Bio-Rad’s custom HuCAL® antibody generation service can satisfy these needs, providing trustworthy antibodies, and overcoming the challenges of antibody generation using immunization of animals.

Advantages of HuCAL Antibody Phage Display

Our recombinant antibodies are selected from the fully synthetic, naïve Human Combinatorial Antibody Libraries (HuCAL) using a proprietary method of phage display. Our latest innovation introduces SpyTag technology to the platform, to build antibodies from modules by protein ligation, and perform site-directed conjugation.

This innovative combination of HuCAL and SpyTag technologies brings you:

  • Rapid custom generation of highly specific Fab antibodies in as little as 8 weeks*
  • Isolation of antibodies against virtually any type of antigen, such as SARS-CoV-2 spike proteins or peptides, and therapeutic drug candidates
  • Fast, flexible format conversion from Fab to IgG, IgM, and IgA
  • Site-directed conjugation with a consistent degree of labeling
  • Sequence defined antibody with a guaranteed long term secure supply

*A Fast Track service for antibody generation in as little as 4 weeks is available subject to feasibility.

Our custom antibody experts are already working with global biopharma and diagnostic companies developing COVID-19 treatments and tests, providing them with custom antibodies as ELISA capture and detection reagents, and serological controls in human IgG, IgM, and IgA isotypes.

Take the next steps to source custom HuCAL antibodies for your SARS-CoV-2 assay development.

  1. Fill in the project form or schedule a call with a technical specialist 
  2. Work with us to design the antibodies you need
  3. Order your custom antibody project
  4. Receive your antibodies within 2-3 months and get your assays started

Our custom antibody laboratory in Neuried, Germany has passed an external risk assessment audit and is accredited with an official occupational safety standard for COVID-19.

Resources

Generation of SARS-CoV-2 Antibodies in Multiple Formats within Four Weeks

Generation of SARS-CoV-2 Antibodies in
Multiple Formats within Four Weeks
 

Learn how our high-throughput generation process
addressed the need for rapid delivery of customized
antibodies during the COVID-19 pandemic.

Listen to Webinar

Custom HuCAL monoclonal antibody generation in detail

Anti-idiotypic antibody generation

Reference

  • Kar S and Islam R (2020). Rapid and robust bioanalytical assays are critical for SARS-CoV-2 therapeutic and vaccine development and beyond. Bioanalysis, 10.4155/bio-2020-0116