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Anti-Panitumumab Antibodies
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Bioanalytical Antibodies
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Antibodies for Bioanalysis and Drug Monitoring
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Antibodies for Bioanalysis and Drug Monitoring
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Antibodies for bioanalysis and drug monitoring of panitumumab and biosimilars
Develop highly selective and sensitive PK and ADA assays for the monoclonal antibody drug panitumumab (Vectibix) using ready-made anti-idiotypic antibodies.
- Inhibitory antibodies specific to panitumumab
- Fully human surrogate positive control or calibrator
- Sequence defined, well characterized reagents with secure supply
- Recombinant production, stringent quality control for batch to batch consistency
- Non-animal-derived antibodies, reducing the use of animals in science
Table 1. Antibodies Specific to Panitumumab.
Specificity |
Catalog Number |
Clone |
Format |
Affinity* KD, nM |
Assay Recommendation |
Product Details |
|---|---|---|---|---|---|---|
|
Panitumumab Inhibitory Type 1 |
HCA264 |
AbD23894 |
Fab-FH1 |
0.3 |
PK bridging ELISA |
|
|
HCA265 |
AbD23897_hIgG1 |
Human IgG1 HRP |
0.3 |
PK bridging ELISA ADA control |
||
|
HCA266 |
AbD23895_hIgG1 |
Human IgG1 |
0.6 |
ADA control |
* Affinity measured in the monovalent Fab format
1 Monovalent Fab antibody DYKDDDDK- and His-6-tags
Anti-Panitumumab Inhibitory Antibodies (Type 1)
Type 1 anti-panitumumab antibodies inhibit the binding of the drug panitumumab to its target, epidermal growth factor receptor (EGFR). They are ideal for development of a pharmacokinetic (PK) bridging ELISA to measure free drug. In fully human IgG1 format they are suitable as a surrogate positive control or calibrator for an anti-drug antibody (ADA) assay.
ELISA Protocols to Get You Started
PK Bridging ELISA
Fig. 1. Panitumumab PK bridging ELISA using antibodies HCA264 and HCA265P.
Schematic image of PK bridging ELISA measuring free drug. Anti-idiotypic capture antibody, Fab format (purple), monoclonal antibody drug (gold), anti-idiotypic detection antibody, Ig format (blue), labeled with HRP.
ADA Bridging ELISA
Fig. 2. Panitumumab ADA bridging ELISA using antibody HCA265 or HCA266.
Schematic image of ADA bridging assay. Monoclonal antibody drug as capture antibody and detection antibody labeled with HRP (gold), fully human anti-idiotypic antibody, Ig format (blue).
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