The cluster of differentiation 3 (CD3) complex serves as a T cell co-receptor that associates non-covalently with the T cell receptor (TCR) making it perfect to use as a T cell marker. We have a wide selection of anti-CD3 products available, suitable for a variety of species, including murine, canine and human antibodies. All these products are available in different formats which you can choose from depending on your requirements, such as low endotoxin, purified, FITC and RPE versions.
Rat anti-Human CD3 antibody, clone CD3-12, specifically recognizes a conserved epitope within the cytoplasmic sequence of the human CD3ε chain. Its broad cross reactivity has been extensively referenced making it an ideal tool for studying T cells in humans and less common species.
CD3 is expressed in mouse T cells and NKT cells. We offer Hamster anti-Mouse CD3 clone 145-2C11 and Rat anti-Mouse clone KT3. Clone 145-2C11 is useful for in vitro blocking and activation assays, as well as apoptosis induction and in vitro T cell depletions. Contrary to KT3, clone 145-2C11 induces cytokine release and morbidity in vivo (Vossen et al. 1995).
We offer Mouse anti-Rat CD3 clone 1F4, which has been demonstrated to induce proliferation of T cells in cell culture (Nicolls et al. 1993).
In the product tables below you can view our anti-CD3 antibodies and our multicolour antibody kits which include CD3.
1. Nicolls MR et al. (1993) Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.
Transplantation. 55(3): 459-68
2. Vossen AC et al. (1995) Fc receptor binding of anti-CD3 monoclonal antibodies is not essential for immunosuppression, but triggers cytokine-related side effects.
Eur J Immunol, 25 (6): 1492-6
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