Innate Immunity Antibodies

CD45R the Marker the Antibodies

CD45 also known as B220, Ly-5 and T200 is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 220 kDa. The PTP family function as signaling molecules in the regulation of many processes such as cell differentiation, division and development (Kaplan et al.1990). There are many different isotypes of CD45 family, with CD45R being the longest protein and with more glycosylation when expressed on B cell. For further information about CD45 and its isoforms refer to the CD45 mini-review. CD45R specifically has been shown to be essential in B cell receptor and T cell receptor signaling. CD45R is primarily found on all developmental B cells including: Pro-B cell, Pre-B cell and up to mature B cells but is also found on T cell & NK cell subsets.


Anti-mouse CD45R clone RA3-6B2 (MCA1258)

  • Reactivity to human
  • Recognizes an epitope on the exon A expressed isotype
  • Recommended applications include: flow cytometry, immunofluorescence, immunohistochemistry – frozen, immunohistochemistry – paraffin section and immunoprecipitation

CD45R (B220) antibody images by application

Flow cytometry
Anti-mouse CD19 V CD45R (B220) Red cell lysed mouse blood stained with CD19FITC (MCA1439) and CD45RPE (MCA1258) in the presence of murine seroblock (BUF041A).

Flow cytometry
Anti-mouse CD28 V CD45R (B220) Red cell lysed mouse blood stained with CD28A647 (MCA2473) and CD45RPE (MCA1258) in the presence of murine seroblock (BUF041A).

CD45R (B220) antibodies

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code

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    Reference

    • Kaplan R et al. (1990). Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci U.S.A. 87(18), 7000-7004.