One of the key attributes of the immune system is its capability to distinguish “self” molecules from “non-self” molecules. While the recognition of foreign antigens is vital for immune responses to pathogens, the failure to recognize self-antigens can result in autoimmune disease. Therefore, to maintain the immune system’s homeostasis and tolerance to self-antigens, the body uses a careful balance of stimulatory and inhibitory signaling through specialized cells.
T helper (Th) cells are able to regulate both the nature and level of the immune response through cytokine signaling (which can influence other immune cells e.g. macrophages) and via direct cell-cell interactions. There are three known T helper cells involved in immune regulation: Th1, Th2 and Th17. In addition, regulatory T cells (Treg cells) are another subpopulation of T cells that can suppress the action of the immune system.
Bio-Rad provides a broad collection of antibodies for use in immune regulation research, all manufactured to ISO 9001 and ISO 13845 quality standards, and guaranteed for use in key applications such as flow cytometry and Western blotting.