CD3 antibody | 145-2C11
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Hamster anti Mouse CD3
- Product Type
- Monoclonal Antibody
|Product Code||Applications||Pack Size||List Price||Your Price||Qty|
|Hamster anti Mouse CD3 antibody, clone 145-2C11 detects CD3 epsilon (CD3ε), a ~20 kDa transmembrane protein also known as CD3 or T3. CD3ε is a member of the CD3 complex which consists of four subunits, gamma, delta, epsilon and zeta, and these are associated to the T cell receptor (TCR). TCR plays a critical role in T cell development and function, and is responsible for ligand recognition. It interacts non-covalently with the CD3 dimers delta/epsilon, gamma/epsilon and zeta/zeta which transduce signals from the TCR into the cell.
CD3ε is primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation.
Hamster anti Mouse CD3 antibody, clone 145-2C11 is useful for in vitro blocking and activation assays, as well as apoptosis induction and in vitro T cell depletions.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Pack Size: 0.1 mg0.09% Sodium Azide (NaN3)Pack Size: 25 µg, 0.25 mg
0.09% Sodium Azide (NaN3)
- Carrier Free
- H-2Kb - specific mouse cytotoxic T lymphocyte clone BM10-37.
- Approx. Protein Concentrations
- Pack Size: 0.1 mgIgG concentration 1.0mg/mlPack Size: 25 µg, 0.25 mgIgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from hyperimmunized Armenian hamsters (Cricetulus migratorius) were fused with cells of the murine SP2/0 myeloma.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Hamster (Armenian) IgG Negative Control||MCA2356||F||0.25 mg||Log in|
|List Price||Your Price|
|Description||Hamster (Armenian) IgG Negative Control|
References for CD3 antibody
Tilley, S.L. et al. (2007) Retinoid-related orphan receptor γ controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen.
J Immunol. 178 (5): 3208-18.
Leo, O. et al. (1987) Identification of a monoclonal antibody specific for a murine T3 polypeptide.
Proc Natl Acad Sci U S A. 84 (5): 1374-8.
Payer, E. et al. (1991) Circulating CD3+/T cell receptor V γ 3+ fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells.
J Immunol. 146 (8): 2536-43.
Salvadori, S. et al. (1994) Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors.
J Immunol. 153 (11): 5176-82.
Podd BS et al. (2006) T cells in cryptopatch aggregates share TCR γ variable region junctional sequences with γδ T cells in the small intestinal epithelium of mice.
J Immunol. 176 (11): 6532-42.
McDole JR et al. (2010) Rapid formation of extended processes and engagement of Theiler’s virus-infected neurons by CNS-infiltrating CD8 T cells.
Am J Pathol. 177 (4): 1823-33.
Lees, C.W. et al. (2008) Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.
PLoS Med. 5: e239.
Klemann, C. et al. (2015) Interleukin-17, Produced by γδ-T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and is Increased in Livers of Patients.
Gastroenterology. pii: S0016-5085(15)01352-9.
View The Latest Product References
Parang, B. et al. (2016) Myeloid translocation genes differentially regulate colorectal cancer programs.
Oncogene. 35 (49): 6341-9.
Schuhmann, M.K. et al. (2017) Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke.
J Neuroinflammation. 14 (1): 18.
Yu, Y. et al. (2017) Conventional alpha beta (αβ) T cells do not contribute to acute intestinal ischemia-reperfusion injury in mice.
PLoS One. 12 (7): e0181326.
Certo, M. et al. (2015) Activation of RXR/PPARγ underlies neuroprotection by bexarotene in ischemic stroke.
Pharmacol Res. 102: 298-307.
Perrotta, M. et al. (2018) Deoxycorticosterone acetate-salt hypertension activates placental growth factor in the spleen to couple sympathetic drive and immune system activation.
Cardiovasc Res. 114 (3): 456-67.
Ohmura, Y. et al. (2021) Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice.
Int J Mol Sci. 22(22):12451.
Shanaki-Bavarsad, M. et al. (2022) Astrocyte-targeted Overproduction of IL-10 Reduces Neurodegeneration after TBI.
Exp Neurobiol. 31 (3): 173-195.
- Entrez Gene
- GO Terms
- GO:0001772 immunological synapse
- GO:0002669 positive regulation of T cell anergy
- GO:0016021 integral to membrane
- GO:0004888 transmembrane receptor activity
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0009897 external side of plasma membrane
- GO:0032729 positive regulation of interferon-gamma production
- GO:0032753 positive regulation of interleukin-4 production
- GO:0042105 alpha-beta T cell receptor complex
- View More GO Terms
- GO:0045060 negative thymic T cell selection
- GO:0045086 positive regulation of interleukin-2 biosynthetic process
- GO:0045879 negative regulation of smoothened signaling pathway
- GO:0046641 positive regulation of alpha-beta T cell proliferation
- GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
- GO:0050850 positive regulation of calcium-mediated signaling
- GO:0050852 T cell receptor signaling pathway
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Mouse Products
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