Protocol: PK Bridging ELISA For Use With Anti-Natalizumab Antibodies
Pharmacokinetic (PK) Bridging ELISA: For use with anti-natalizumab monoclonal antibody products HCA248 and HCA249P
This method provides a procedure for carrying out a PK ELISA with anti-natalizumab antibodies, product codes HCA248 (capture antibody) and HCA249P (detection antibody), and using natalizumab monoclonal antibody for the standard curve.
The method should always be used in conjunction with product and batch specific information provided with each vial (see product datasheets). This protocol will need to be adjusted for use with different detection methods and immunoassay technology platforms.
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