CD41/CD61 antibody | 11C3
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|Mouse anti Chicken CD41/61, clone 11C3 recognizes chicken integrin CD41/61, also known as GPIIb-IIIa. CD41/61 is a heterodimeric cell surface protein, expressed on chicken thrombocytes and cells of the thrombocyte lineage. Avian thrombocytes are nucleated equivalents of mammalian platelets playing roles in coagulation and phagocytosis.
Mouse anti Chicken CD41/61 clone 11C3 is reported to induce thrombocyte activation (Lacoste-Eleaume et al. 1994).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Peripheral blood leukocytes from white leghorn chicken
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the X63/A63-653 myeloma cell line
- For research purposes only
- 12 months from date of despatch
- This antibody is licensed from INRA-INSERM
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul
Lacoste-Eleaume, A.S. et al. (1994) Biochemical and functional characterization of an avian homolog of the integrin GPIIb-IIIa present on chicken thrombocytes.
Exp Cell Res. 213 (1): 198-209.
References for CD41/CD61 antibody
Horiuchi, H. et al. (2004) A monoclonal antibody against chicken thrombocytes reacts with the cells of thrombocyte lineage.
J Vet Med Sci. 66 (3): 243-50.
Corbel, C. (2002) Expression of alphaVbeta3 integrin in the chick embryo aortic endothelium.
Int J Dev Biol. 46 (6): 827-30.
Del Cacho, E. et al. (2008) Isolation of chicken follicular dendritic cells.
J Immunol Methods. 334: 59-69.
Del Cacho, E. et al. (2009) Avian follicular and interdigitating dendritic cells: isolation and morphologic, phenotypic, and functional analyses.
Vet Immunol Immunopathol. 129: 66-75.
Ody, C. et al. (1999) Glycoprotein IIb-IIIa is expressed on avian multilineage hematopoietic progenitor cells.
Blood 93: 2898-906.
Chaussé, A.M. et al. (2011) Expression of Toll-like receptor 4 and downstream effectors in selected cecal cell subpopulations of chicks resistant or susceptible to Salmonella carrier state.
Infect Immun. 79: 3445-54.
Balic, A. et al. (2014) Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage.
Development 141: 3255-65.
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