CD41 | Integrin Alpha Chain 2B


Integrin alpha chain 2b, also known as CD41, is an heterodimeric integral membrane protein. It undergoes post-translational modifications that result in two polypeptide chains linked by a disulfide bond. CD41 is expressed on platelets and megakaryocytes, but also on early embryonic hematopoietic stem cells.

The integrin alpha chain associates with a beta 3 chain, CD61. The resulting CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin, and has a crucial role in coagulation. Mutations that impair its role in coagulation result in thrombasthenia.

Integrins also partecipate in cell surface-mediated signaling. Clone (MWReg30) has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo.

Recent Publications with our Antibodies

Mouse Anti Human CD41 Clone PM6/248 FITC Conjugated

  1. Vettore S et al (2008) Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant.
    Haematologica Nov;93(11):1743-7

Mouse Anti Human CD41 Clone PM6/248 AlexaFluor 647 Conjugated

  1. Maloney SF et al (2010) P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.
    Integr Biol (Camb). Apr 7;2(4):183-92

Rat Anti Mouse CD41 Clone MWReg30 biotin Conjugated

  1. Perez EL et al (2008) SH2-Inositol Phosphatase 1 Negatively Influences Early Megakaryocyte Progenitors.
    PLoS One 3(10):e3565