Integrin alpha chain 2b, also known as CD41, is an heterodimeric integral membrane protein. It undergoes post-translational modifications that result in two polypeptide chains linked by a disulfide bond. CD41 is expressed on platelets and megakaryocytes, but also on early embryonic hematopoietic stem cells.
The integrin alpha chain associates with a beta 3 chain, CD61. The resulting CD41/CD61 complex is a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin and thrombospondin, and has a crucial role in coagulation. Mutations that impair its role in coagulation result in thrombasthenia.
Integrins also partecipate in cell surface-mediated signaling. Clone (MWReg30) has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo.
Mouse Anti Human CD41 Clone PM6/248 FITC Conjugated
Mouse Anti Human CD41 Clone PM6/248 AlexaFluor 647 Conjugated
Rat Anti Mouse CD41 Clone MWReg30 biotin Conjugated