Trem-1 antibody | TREM-37
Mouse anti Human Trem-1 antibody, clone TREM-37 (MCA4697T) used to assess TREM-1 levels in endothlial cell lysates by western blotting.
Image caption:
SLC-TREM-1 enters into endothelial cells and decreases TREM-1 expression. (D) SLC-TREM-1 decreased 4 h LPS (100 ng/mL)-induced TREM-1 up-regulation on endothelial cells as assessed by Western blot (SLC 250 or 500 nM)
From: Gibot S, Jolly L, Lemarié J, Carrasco K, Derive M, Boufenzer A.
Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation.
Front Immunol. 2019 Oct 1;10:2314.
doi: 10.3389/fimmu.2019.02314..
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Human Trem-1
- Product Type
- Monoclonal Antibody
- Clone
- TREM-37
- Isotype
- IgG2b
- Specificity
- Trem-1
Antibody Quality and Performance Guarantee
| Mouse anti Human Trem-1 antibody, clone TREM-37 recognizes triggering receptor expressed on myeloid cells 1 also known as TREM-1, Triggering receptor expressed on monocytes 1 or CD354. Trem-1 is a 214 amino acid ~22 kDa single pass type 1 transmembrane immune receptor expressed on CD14+ monocytes, macrophages and neutrophils, highly expressed in inflammatory lesions caused by fungi and bacteria. It stimulates neutrophil and monocyte-mediated inflammatory responses. TREM-1 activation, together with LPS and other PRR ligands, amplifies the production pro-inflammatory cytokines and thus the inflammatory response. TREM-1 also plays a crucial role in the mediation of septic shock (Bouchon et al. 2001). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Recombinant human TREM-1.
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
||
| Western Blotting | |
1ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG2b Negative Control | MCA691 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG2b Negative Control | ||||||
References for Trem-1 antibody
-
Chimma, P. et al. (2009) A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria.
PLoS Pathog. (10):e1000631. -
Gibot, S. et al. (2019) Triggering Receptor Expressed on Myeloid Cells-1 Inhibitor Targeted to Endothelium Decreases Cell Activation.
Front Immunol. 10: 2314.
- RRID
- AB_2208557
- UniProt
- Q9NP99
- Entrez Gene
- TREM1
- GO Terms
- GO:0005886 plasma membrane
- GO:0007596 blood coagulation
- GO:0016021 integral to membrane
- GO:0005576 extracellular region
- GO:0004872 receptor activity
- GO:0035556 intracellular signal transduction
- GO:0006959 humoral immune response
- GO:0050900 leukocyte migration
MCA4697T
148568
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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