PTEN Tumor Suppressor Protein antibody | A2b1
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Mouse anti PTEN tumour suppressor antibody, clone A2b1, is specific for PTEN, a tumour suppressor protein located on the human chromosome 10 that is often mutated in various types of advanced cancers.PTEN exhibits protein phosphatase activity and can suppress the growth of glioma cells.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- A 10 amino acid peptide corresponding to a region towards to the C-terminus of native PTEN
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P60484
- O08586
- Entrez Gene
- Pten
- PTEN
- GO Terms
- GO:0000287 magnesium ion binding
- GO:0001525 angiogenesis
- GO:0002902 regulation of B cell apoptosis
- GO:0051726 regulation of cell cycle
- GO:0006915 apoptosis
- GO:0004438 phosphatidylinositol-3-phosphatase activity
- GO:0004722 protein serine/threonine phosphatase activity
- GO:0004725 protein tyrosine phosphatase activity
- GO:0006470 protein dephosphorylation
- GO:0006917 induction of apoptosis
- GO:0007417 central nervous system development
- GO:0008138 protein tyrosine/serine/threonine phosphatase activity
- GO:0010975 regulation of neuron projection development
- GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
- GO:0016605 PML body
- GO:0030165 PDZ domain binding
- GO:0030336 negative regulation of cell migration
- GO:0033032 regulation of myeloid cell apoptosis
- GO:0043066 negative regulation of apoptosis
- GO:0043542 endothelial cell migration
- GO:0046855 inositol phosphate dephosphorylation
- GO:0046856 phosphatidylinositol dephosphorylation
- GO:0048738 cardiac muscle tissue development
- GO:0050680 negative regulation of epithelial cell proliferation
- GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
- GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
- GO:0051895 negative regulation of focal adhesion assembly
- GO:0051898 negative regulation of protein kinase B signaling cascade
- GO:0060736 prostate gland growth
- GO:0000079 regulation of cyclin-dependent protein kinase activity
- GO:0001933 negative regulation of protein phosphorylation
- GO:0005829 cytosol
- GO:0008289 lipid binding
- GO:0008283 cell proliferation
- GO:0009898 internal side of plasma membrane
- GO:0050821 protein stabilization
- GO:0019899 enzyme binding
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050852 T cell receptor signaling pathway
- GO:0051091 positive regulation of transcription factor activity
- GO:0060070 canonical Wnt receptor signaling pathway
- Regulatory
- For research purposes only
Applications of PTEN Tumor Suppressor Protein antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Frozen 1 | 1/20 | 1/50 | |
| Immunohistology - Paraffin | |||
| Immunoprecipitation | 1/10 | 1/20 | |
| Western Blotting | 1/100 |
- 1The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Bio-Rad recommends the use of acetone fixation for frozen sections.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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