PTEN Tumor Suppressor Protein antibody | A2b1

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Mouse anti PTEN Tumor Suppressor Protein

Product Type
Monoclonal Antibody
Clone
A2b1
Isotype
IgG1
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
OBT1120 C* IP WB 0.1 mg
Mouse anti PTEN tumour suppressor antibody, clone A2b1, is specific for PTEN, a tumour suppressor protein located on the human chromosome 10 that is often mutated in various types of advanced cancers.
PTEN exhibits protein phosphatase activity and can suppress the growth of glioma cells.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
Immunogen
A 10 amino acid peptide corresponding to a region towards to the C-terminus of native PTEN
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P60484 Related reagents
O08586 Related reagents
Entrez Gene
Pten Related reagents
PTEN Related reagents
GO Terms
GO:0000287 magnesium ion binding
GO:0001525 angiogenesis
GO:0002902 regulation of B cell apoptosis
GO:0051726 regulation of cell cycle
GO:0006915 apoptosis
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0006470 protein dephosphorylation
GO:0006917 induction of apoptosis
GO:0007417 central nervous system development
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0010975 regulation of neuron projection development
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016605 PML body
GO:0030165 PDZ domain binding
GO:0030336 negative regulation of cell migration
GO:0033032 regulation of myeloid cell apoptosis
GO:0043066 negative regulation of apoptosis
GO:0043542 endothelial cell migration
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048738 cardiac muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0051895 negative regulation of focal adhesion assembly
GO:0051898 negative regulation of protein kinase B signaling cascade
GO:0060736 prostate gland growth
GO:0000079 regulation of cyclin-dependent protein kinase activity
GO:0001933 negative regulation of protein phosphorylation
GO:0005829 cytosol
GO:0008289 lipid binding
GO:0008283 cell proliferation
GO:0009898 internal side of plasma membrane
GO:0050821 protein stabilization
GO:0019899 enzyme binding
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048011 nerve growth factor receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051091 positive regulation of transcription factor activity
GO:0060070 canonical Wnt receptor signaling pathway
Regulatory
For research purposes only

Applications of PTEN Tumor Suppressor Protein antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen 1 1/20 1/50
Immunohistology - Paraffin
Immunoprecipitation 1/10 1/20
Western Blotting 1/100
  1. 1The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Bio-Rad recommends the use of acetone fixation for frozen sections.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Human anti Mouse IgG1:HRP HCA036P 0.1 mg E
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) STAR117A 0.5 mg E WB
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed) STAR117D488GA 0.1 mg F IF
Goat anti Mouse IgG (H/L):DyLight®549 (Multi Species Adsorbed) STAR117D549GA 0.1 mg F IF WB
Goat anti Mouse IgG (H/L):DyLight®649 (Multi Species Adsorbed) STAR117D649GA 0.1 mg F IF
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA 0.1 mg F WB
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA 0.1 mg F IF WB
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) STAR117F 0.5 mg F
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed) STAR117P 0.5 mg E WB
Goat anti Mouse IgG (Fc):FITC STAR120F 1 mg C F
Goat anti Mouse IgG (Fc):HRP STAR120P 1 mg E WB
Rabbit F(ab')2 anti Mouse IgG:RPE STAR12A 1 ml F
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed) STAR13B 1 mg C E P RE WB
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 0.5 mg F
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 1 ml F
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 0.5 mg C E P
Goat anti Mouse IgG/A/M:Alk. Phos. STAR87A 1 mg C E WB
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P 1 mg E
Rabbit F(ab')2 anti Mouse IgG:Dylight®800 STAR8D800GA 0.1 mg F IF WB
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B 1 mg F