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Protocol: Pharmacokinetic (PK) ELISA Antigen Capture Format
Phamacokinetic (PK) ELISA Antigen Capture Format: for Use with Anti-Durvalumab Antibody TZA002
This method provides a procedure for carrying out a PK ELISA antigen capture format with Anti-Durvalumab Antibody, TZA002 (detection antibody), and using durvalumab for the standard curve. Anti-durvalumab drug/target complex antibody recognizes durvalumab only when bound to its target human programmed cell death ligand 1 (PD-L1). It does not recognize the free drug or unbound human PD-L1. The method should always be used in conjunction with product and batch specific information provided with each vial (see product datasheets). This protocol will need to be adjusted for use with different detection methods and immunoassay technology platforms.