Thyroid Stimulating Hormone Receptor antibody | 4C1
Mouse anti Human Thyroid Stimulating Hormone Receptor
- Product Type
- Monoclonal Antibody
- Clone
- 4C1
- Isotype
- IgG2a
- Specificity
- Thyroid Stimulating Hormone Receptor
Mouse anti Human thyroid stimulating hormone receptor, clone 4C1 recognizes the human thyroid stimulating hormone receptor (hTSHR), otherwise known as the thyrotropin receptor. Mouse anti Human thyroid stimulating hormone receptor, clone 4C1 binds to an extracellular domain of hTSHR. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- MCA1571T: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- MCA1571: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- External domain of human TSH receptor.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c mice were fused with cells of the NS1/Ag4.1 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- MCA1571T: 12 months from date of despatch
- MCA1571: 12 months from date of despatch.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | |||
Flow Cytometry | 1/100 | 1/1000 | |
Immunohistology - Frozen | |||
Immunohistology - Paraffin | 1/1000 | 1/2000 | |
Immunoprecipitation | |||
Western Blotting | 1/1000 |
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
- Histology Positive Control Tissue
- Human thyroid gland
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse IgG2a Negative Control | MCA929 | F | 100 Tests | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Mouse IgG2a Negative Control |
References for Thyroid Stimulating Hormone Receptor antibody
-
(0) Human Protein Atlas: CAB000473
Human Protein Atlas: CAB000473 -
Shepherd PS,et al. (1999) Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.
Mol Cell Endocrinol.149:197-206. -
Suh, J.M. et al. (2003) Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.
J Biol Chem. 278 (24): 21960-71. -
Kleinau, G. et al. (2011) From Molecular Details of the Interplay between Transmembrane Helices of the Thyrotropin Receptor to General Aspects of Signal Transduction in Family A G-protein-coupled Receptors (GPCRs).
J Biol Chem. 286: 25859-71. -
Oba, J. et al. (2017) Trends in hepatocyte growth factor, insulin-like growth factor 1, thyroid-stimulating hormone, and leptin expression levels in uveal melanoma patient serum and tumor tissues: correlation to disease progression.
Melanoma Res. 27 (2): 126-33.
- Synonyms
- Thyrotropin Receptor
- RRID
- AB_2272242
- UniProt
- P16473
- Entrez Gene
- TSHR
- GO Terms
- GO:0005515 protein binding
- GO:0004996 thyroid-stimulating hormone receptor activity
- GO:0005887 integral to plasma membrane
- GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
- GO:0007267 cell-cell signaling
- GO:0008284 positive regulation of cell proliferation
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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