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Thyroid Stimulating Hormone Receptor antibody | 4C1

Mouse anti Human Thyroid Stimulating Hormone Receptor

Product Type
Monoclonal Antibody
Clone
4C1
Isotype
IgG2a
Specificity
Thyroid Stimulating Hormone Receptor

Product Code Applications Pack Size List Price Your Price Qty
MCA1571T
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F P 20 µg loader
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loader
MCA1571
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F IP P WB 0.2 mg loader
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loader

Mouse anti Human thyroid stimulating hormone receptor, clone 4C1 recognizes the human thyroid stimulating hormone receptor (hTSHR), otherwise known as the thyrotropin receptor. Mouse anti Human thyroid stimulating hormone receptor, clone 4C1 binds to an extracellular domain of hTSHR.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
MCA1571T: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
MCA1571: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
External domain of human TSH receptor.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunized BALB/c mice were fused with cells of the NS1/Ag4.1 myeloma cell line.
Regulatory
For research purposes only
Guarantee
MCA1571T: 12 months from date of despatch
MCA1571: 12 months from date of despatch.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Flow Cytometry 1/100 1/1000
Immunohistology - Frozen
Immunohistology - Paraffin 1/1000 1/2000
Immunoprecipitation
Western Blotting 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl
Histology Positive Control Tissue
Human thyroid gland

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Description Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (Fc):FITC
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Description Goat anti Mouse IgG (Fc):HRP
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Description Rabbit F(ab')2 anti Mouse IgG:RPE
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Description Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed)
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 F 0.5 mg loader
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Description Goat anti Mouse IgG:FITC (Rat Adsorbed)
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 F 1 ml loader
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Description Goat anti Mouse IgG:RPE (Rat Adsorbed)
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 C E P 0.5 mg loader
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Description Goat anti Mouse IgG:HRP (Rat Adsorbed)
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P E 1 mg loader
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Description Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B F 1 mg loader
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Description Rabbit F(ab')2 anti Mouse IgG:FITC

Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse IgG2a Negative Control MCA929 F 100 Tests loader
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Description Mouse IgG2a Negative Control

References for Thyroid Stimulating Hormone Receptor antibody

  1. (0) Human Protein Atlas: CAB000473
    Human Protein Atlas: CAB000473
  2. Shepherd PS,et al. (1999) Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.
    Mol Cell Endocrinol.149:197-206.
  3. Suh, J.M. et al. (2003) Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.
    J Biol Chem. 278 (24): 21960-71.
  4. Kleinau, G. et al. (2011) From Molecular Details of the Interplay between Transmembrane Helices of the Thyrotropin Receptor to General Aspects of Signal Transduction in Family A G-protein-coupled Receptors (GPCRs).
    J Biol Chem. 286: 25859-71.
  5. Oba, J. et al. (2017) Trends in hepatocyte growth factor, insulin-like growth factor 1, thyroid-stimulating hormone, and leptin expression levels in uveal melanoma patient serum and tumor tissues: correlation to disease progression.
    Melanoma Res. 27 (2): 126-33.

Immunohistology - Paraffin

Synonyms
Thyrotropin Receptor
RRID
AB_2272242
UniProt
P16473
Entrez Gene
TSHR
GO Terms
GO:0005515 protein binding
GO:0004996 thyroid-stimulating hormone receptor activity
GO:0005887 integral to plasma membrane
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation

MCA1571T

151042 1808

MCA1571

155878 161432 1702

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