We offer an extensive range of monoclonal and polyclonal antibodies to thyroid hormones, for research purposes as well as diagnostic assay development.
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid gland. TSH is composed of two subunits, alpha subunit binds to beta subunit. The alpha subunit is almost identical to that of human chorionic gonadotropin (hCG), follicle-stimulating hormone (FSH), and luteinising hormone (LH). The beta subunit is unique to TSH and determines its receptor specificity.
A TSH assay is a recommended screening tool for thyroid diseases, as well as part of tests for determination of excess (hyperthyroidism) or deficiency (hypothyroidism) of thyroid hormones.
The TSH receptor (or thyrotropin receptor) is a G protein-coupled transmembrane receptor that is primarily found on the surface of the thyroid epithelial cells. It responds to TSH and stimulates the production of thyroxine (T4) and triiodothyronine (T3). TSH receptor has also been found to be related to autoimmune thyroid diseases, such as hyperthyroidism of Graves’ Disease and hypothyrioidism of Hashimoto’s thyroiditis.