Somatostatin Receptor 4 antibody | sstr4
|Mouse anti Human Somatostatin Receptor 4 antibody, clone sstr4 recognizes human somatostatin receptor 4, a 388 amino acid multi pass transmembrane glycoprotein freceptor for somatostatin-14. Somatostatin (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.
The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.
Mouse anti Human Somatostatin Receptor 4 antibody, clone sstr4 specifically recognises SSTR type 4, but none of the other SSTR subtypes. Bio-Rad also has antibodies to SSTR subtypes 1, 3 and 5 (MCA5924, MCA5921, MCA5923) available.
- Target Species
- Product Form
- Purified IgG - liquid
- Antibody purified from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Synthetic peptide, sequence CQQEALQPEPGRKRIPLT.
- Approx. Protein Concentrations
- IgG concentration 1mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Paraffin|
- Histology Positive Control Tissue
- Human lung tissue
References for Somatostatin Receptor 4 antibody
Schmid, H.A. et al. (2012) Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors.
Neuroendocrinology. 95 (3): 232-47.
Leijon, H. et al. (2018) Variable somatostatin receptor subtype expression in 151 primary pheochromocytomas and paragangliomas.
Hum Pathol. Dec 07 [Epub ahead of print].
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