Somatostatin Receptor 4 antibody | sstr4

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Mouse anti Human Somatostatin Receptor 4

Product Type
Monoclonal Antibody
Clone
sstr4
Isotype
IgG2a
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
MCA5922 P 0.2 mg
Mouse anti Human Somatostatin Receptor 4 antibody, clone sstr4 recognizes human somatostatin receptor 4, a 388 amino acid multi pass transmembrane glycoprotein freceptor for somatostatin-14. Somatostatin (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.

The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.

Mouse anti Human Somatostatin Receptor 4 antibody, clone sstr4 specifically recognises SSTR type 4, but none of the other SSTR subtypes. Bio-Rad also has antibodies to SSTR subtypes 1, 3 and 5 (MCA5924, MCA5921, MCA5923) available.

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Carrier Free
Yes
Immunogen
Synthetic peptide, sequence CQQEALQPEPGRKRIPLT.
Approx. Protein Concentrations
IgG concentration 1mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P31391 Related reagents
Entrez Gene
SSTR4 Related reagents
GO Terms
GO:0004994 somatostatin receptor activity
GO:0005887 integral to plasma membrane
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0008285 negative regulation of cell proliferation
Regulatory
For research purposes only

Applications of Somatostatin Receptor 4 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human lung tissue

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Human anti Mouse IgG2a:FITC HCA037F 0.1 mg F
Human anti Mouse IgG2a:HRP HCA037P 0.1 mg E
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) STAR117A 0.5 mg E WB
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed) STAR117D488GA 0.1 mg F IF
Goat anti Mouse IgG (H/L):DyLight®549 (Multi Species Adsorbed) STAR117D549GA 0.1 mg F IF WB
Goat anti Mouse IgG (H/L):DyLight®649 (Multi Species Adsorbed) STAR117D649GA 0.1 mg F IF
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA 0.1 mg F WB
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA 0.1 mg F IF WB
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) STAR117F 0.5 mg F
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed) STAR117P 0.5 mg E WB
Goat anti Mouse IgG (Fc):FITC STAR120F 1 mg C F
Goat anti Mouse IgG (Fc):HRP STAR120P 1 mg E WB
Rabbit F(ab')2 anti Mouse IgG:RPE STAR12A 1 ml F
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed) STAR13B 1 mg C E P RE WB
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 0.5 mg F
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 1 ml F
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 0.5 mg C E P
Goat anti Mouse IgG/A/M:Alk. Phos. STAR87A 1 mg C E WB
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P 1 mg E
Rabbit F(ab')2 anti Mouse IgG:Dylight®800 STAR8D800GA 0.1 mg F IF WB
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B 1 mg F

Product Specific References

References for Somatostatin Receptor 4 antibody

  1. Schmid, H.A. et al. (2012) Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors.
    Neuroendocrinology. 95 (3): 232-47.