Fig 1. Paraffin embedded human pancreas stained with Mouse anti Human somatostatin receptor 1, followed by Histar Detection Kit (STAR3000A). No antigen retrieval was used
Four highly specific monoclonal antibodies to somatostatin receptors for use in immunohistochemistry on paraffin-embedded sections.
Somatostatin receptors (SSTR) are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumors, with tumors often expressing more than one subtype in different combinations.
Each of our anti-somatostatin receptor monoclonal antibodies is highly specific to the individual receptor subtype and shows no cross reactivity with the other SSTR subtypes. Somatostatin receptor subtype-specific antibodies enable the identification of the SSTR expression profile of patient samples, and facilitate discovery research into SSTR function, for example in neuroendocrine tumors and non-medullary thyroid carcinomas.
The peptide hormone somatostatin (SST) has wide ranging inhibitory effects on cell proliferation and hormone secretion. The large precursor molecule to somatostatin, preproSST, is cleaved to produce one of two active forms: SST-14, a 14 amino acid peptide, or SST-28, a 28 amino acid peptide. Knowledge about the inhibitory effects of somatostatins on hormone release and cell growth has led to the use of its synthetic analogs for the treatment of neuroendocrine tumors and other neuroendocrine diseases. For example, octreotide and lanreotide are stable synthetic derivatives of SST in clinical use.
The effects of SST are mediated via five distinct G protein-coupled receptors. The receptors have similar affinities for natural SST-14 and SST-28, but have different affinity for the synthetic analogs.