Rragc antibody | AB02/2G5

Mouse anti Human Rragc

Product Type
Monoclonal Antibody
Clone
AB02/2G5
Isotype
IgG1
Format
Purified
Specificity
Rragc

Product Code Applications Pack Size List Price Your Price Qty
New MCA6409GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
List Price Your Price
loader

Mouse anti Human RRAGC antibody recognizes ras-related GTP-binding protein C subunit beta-1, otherwise known as GTPase-interacting protein 2.

RRAGC is a monomeric guanine nucleotide binding protein that functions as a heterodimer with rag A or rag B. The binding of this heterodimer to mTORC1 leads to mTORC1 being recruited to the surface of lysosomes; thereby enabling mTORC1 to associate with rheb and become activated (Sancak et al. 2010; Yang et al. 2017). Upon amino acid depletion, Rag heterodimers release mTORC1 into the cytosol; suggesting that Rags control mTORC1 signaling in response to amino acid levels (Fingar, 2021).

Mouse anti Human RRAGC antibody detects a band of 49 kDa.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti Human RRAGC antibody detects a band of 49 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli-derived recombinant protein, aa 1-399 of human RRAGC
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)
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Description Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed)
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Description Goat anti Mouse IgG (Fc):FITC
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Description Goat anti Mouse IgG (Fc):HRP
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Description Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed) STAR117D650 F IF 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed) STAR117D550 F IF WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG/A/M:Alk. Phos.
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B F 1 mg loader
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Description Rabbit F(ab')2 anti Mouse IgG:FITC

UniProt
Q9HB90
Entrez Gene
RRAGC
GO Terms
GO:0003924 GTPase activity
GO:0000287 magnesium ion binding
GO:0016049 cell growth
GO:0006915 apoptosis
GO:0005764 lysosome
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0006350 transcription
GO:0007264 small GTPase mediated signal transduction
GO:0008380 RNA splicing
GO:0019003 GDP binding
GO:0032008 positive regulation of TOR signaling cascade
GO:0034613 cellular protein localization
GO:0046982 protein heterodimerization activity
GO:0071230 cellular response to amino acid stimulus

MCA6409GA

100007432

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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