MBP antibody | 22
Filter by Application:C Reset
|Mouse anti MBP antibody, clone 22 recognizes an epitope between amino acids 84 and 89 of human myelin basic protein, also known as MBP, Myelin A1 protein or Myelin membrane encephalitogenic protein. MBP is a 304 amino acid ~33 kDa abundant component of the myelin membrane. There are 6 potential isoforms of MBP generated by alternative splicing, 4 of which lack the N-terminal region containing the immunogen sequence. Mouse anti MBP antibody, clone 22 is expected to recognize isoforms 1 and 2 (UniProt: P02686). The N-terminal region of MBP is highly conserved and Mouse anti MBP antibody, clone 22 is expected to be broadly species cross reactive for isoforms maintaining the N-terminal region. Mouse anti MBP antibody, clone 22 has been reported as suitable for use in western blotting (Chignola et al. 2000).|
- Target Species
- Product Form
- Tissue Culture Supernatant - liquid
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human myelin basic protein.
- Fusion Partners
- Spleen cells from immunized mice were fused with cells of the mouse SP2/0 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Immunohistology - Paraffin|
- Histology Positive Control Tissue
References for MBP antibody
Chignola, R. et al. (2000) Expression of myelin basic protein (MBP) epitopes in human non-neural cells revealed by two anti-MBP IgM monoclonal antibodies.
Clin Exp Immunol. 122 (3): 429-36.
Groome, N. et al. (1988) New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein.
J Neuroimmunol. 19 (4): 305-15.
Martenson, R. E. (1984) Experimental allergic encephalomyelitis. A useful model of multiple sclerosis.
Eds Alvord, Kies and Suckling pp 511-521. Alan Liss N.Y.
Harrower, T.P. et al. (2006) Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease.
Exp Neurol. 197 (1): 56-69.
Liao, M.C. et al. (2009) Degradation of amyloid beta protein by purified myelin basic protein.
J Biol Chem. 284: 28917-25.
Diemel, L.T. et al. (2003) Role for TGF-beta1, FGF-2 and PDGF-AA in a myelination of CNS aggregate cultures enriched with macrophages.
J Neurosci Res. 74 (6): 858-67.
Always be the first to know.
When we launch new products and resources to help you achieve more in the lab.Yes, sign me up