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LAMTOR1 antibody | rCD01/3G6

Mouse anti Human LAMTOR1

Product Type
Monoclonal Antibody
Clone
rCD01/3G6
Isotype
IgG2a
Specificity
LAMTOR1

Product Code Applications Pack Size List Price Your Price Qty
New MCA6439GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
List Price Your Price
loader

Mouse anti human LAMTOR1 antibody, clone rCD01/3G6 recognizes Ragulator complex protein LAMTOR1, also known as late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. LAMTOR1 is a 17kDa protein that associates with LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 to form the pentameric Ragulator complex. LAMTOR1 is directly involved in the anchoring of the Ragulator complex to the lysosomal membrane where it regulates cell metabolism and growth by coordinating the activities of metabolic signaling patways with nutrient availability.

The downregulation of LAMTOR1 affects lysosomal activation, leading to an aberrant lysosomal catabolism that produces excessive reactive oxygen species that in turn triggers p53-dependent cell cycle arrest and apoptosis (Malek et al.,2021). In cancer, LAMTOR1 has also been shown to facilitate immune escape by targeting MHC-II molecules via endocytic degradation (Wu et al.,2022)

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified recombinant IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Source
CHO-S
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli-derived recombinant protein, amino acids 1-162 of human LAMTOR1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) STAR117A E WB 0.5 mg loader
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Description Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed) STAR117D488GA F IF 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed) STAR117D550 F IF WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed) STAR117D650 F IF 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA F WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA F IF WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) STAR117F F 0.5 mg loader
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Description Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed) STAR117P C E WB 0.5 mg loader
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Description Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)
Goat anti Mouse IgG (Fc):FITC STAR120F C F 1 mg loader
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Description Goat anti Mouse IgG (Fc):FITC
Goat anti Mouse IgG (Fc):HRP STAR120P E WB 1 mg loader
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Description Goat anti Mouse IgG (Fc):HRP
Rabbit F(ab')2 anti Mouse IgG:RPE STAR12A F 1 ml loader
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Description Rabbit F(ab')2 anti Mouse IgG:RPE
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed) STAR13B C E P RE WB 1 mg loader
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Description Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed)
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 F 0.5 mg loader
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Description Goat anti Mouse IgG:FITC (Rat Adsorbed)
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 F 1 ml loader
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Description Goat anti Mouse IgG:RPE (Rat Adsorbed)
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 C E P 0.5 mg loader
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Description Goat anti Mouse IgG:HRP (Rat Adsorbed)
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P E 1 mg loader
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Description Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B F 1 mg loader
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Description Rabbit F(ab')2 anti Mouse IgG:FITC

UniProt
Q6IAA8
Entrez Gene
LAMTOR1
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0016049 cell growth
GO:0001919 regulation of receptor recycling
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0008289 lipid binding
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0010872 regulation of cholesterol esterification
GO:0010874 regulation of cholesterol efflux
GO:0032008 positive regulation of TOR signaling cascade
GO:0032418 lysosome localization
GO:0032439 endosome localization
GO:0034613 cellular protein localization
GO:0042632 cholesterol homeostasis
GO:0043410 positive regulation of MAPKKK cascade
GO:0060620 regulation of cholesterol import
GO:0071230 cellular response to amino acid stimulus
GO:0071986 Ragulator complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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