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IgA1 antibody | B3506B4

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Anti Human IgA1 Alpha 1 Chain Antibody, clone B3506B4 thumbnail image 1 Anti Human IgA1 Alpha 1 Chain Antibody, clone B3506B4 thumbnail image 2
Anti Human IgA1 Alpha 1 Chain Antibody, clone B3506B4 gallery image 1
Published customer image:
HRP conjugated Mouse anti Human IgA1 antibody, clone B3506B4 (913005) used for the evaluation of IgA1 levels in human serum samples by ELISA.
Image caption:
Comparison of serum IgA in patients with IgA nephropathy and heathy subjects. J-IgA: joining chain-containing IgA; J-IgA1: joining chain-containing IgA1; IgAN: IgA nephropathy; NC: normal control. Statistically significant differences were tested with Mann–Whitney U-test.

From: Li G, Wang X, Yang Z, Zhao Q, Wen Y, Li X, Gao R.
Serum Levels of Joining Chain-Containing IgA1 Are Not Elevated in Patients with IgA Nephropathy.
Dis Markers. 2019 Jul 2;2019:9802839.
doi: 10.1155/2019/9802839.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Anti Human IgA1 Alpha 1 Chain Antibody, clone B3506B4 gallery image 2
Published customer image:
HRP conjugated Mouse anti Human IgA1 antibody, clone B3506B4 (913005) used for the evaluation of IgA1 levels in plasma samples by western blotting.
Image caption:
Verification of successful preparation of ddIgA1 and IgG-dd-IgA1 complexes. a Glycosylation status of IgA1 and ddIgA1 were detected by two lectins, SNA and VVL, which recognized sialic acid (SA), and N-Acetylgalactosamine (GalNAc), respectively. IgA1 molecules showed high binding capacity to SNA (blank column) and low binding capacity to VVL (filled column). In contrary, ddIgA1 showed low binding capacity to SNA (blank column) and high binding capacity to VVL (filled column). b Existence of dd-IgA1 (upper panel) and IgG (lower panel) in IgG-ddIgA1 complexes were tested by Western blot analysis. Both IgA1 and IgG were existence in IgG-ddIgA1 complexes of recruited individuals (lane 1–4). Isolated ddIgA1 (lane 5), IgA1 (lane 6) and IgG (lane 7) were used as references

From: Zhao YF, Zhu L, Liu LJ, Shi SF, Lv JC, Zhang H.
Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy.
BMC Nephrol. 2017 Sep 29;18(1):301.
doi: 10.1186/s12882-017-0722-3.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.

Mouse anti Human IgA1 Alpha 1 Chain:Biotin

Product Type
Monoclonal Antibody
Clone
B3506B4
Isotype
IgG1
Specificity
IgA1

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Product Code Applications Pack Size List Price Your Price Qty
913008
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E IB WB 0.5 mg loader
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Mouse anti Human IgA1 antibody, clone B3506B4 recognizes the Fc portion of the heavy chain of human IgA1 as demonstrated by ELISA.

Target Species
Human
Product Form
Purified IgG conjugated to Biotin - liquid
Preparation
Purified IgG prepared from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Human IgA1 heavy chains.
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunoblotting
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for IgA1 antibody

  1. Zhao, Y.F. et al. (2017) Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy.
    BMC Nephrol. 18 (1): 301.
  2. Li, G. et al. (2019) Serum Levels of Joining Chain-Containing IgA1 Are Not Elevated in Patients with IgA Nephropathy.
    Dis Markers. 2019: 9802839.

RRID
AB_616707
UniProt
P01876
Entrez Gene
IGHA1
GO Terms
GO:0005515 protein binding
GO:0003823 antigen binding
GO:0006955 immune response
GO:0018298 protein-chromophore linkage

913008

155251 157333 158072 159077

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