IgA | Immunoglobulin A Class

Author: Misha Rahman, Ph.D.

H uman immunoglobulin A (IgA) is the second most common human immunoglobulin in serum. It is secreted in milk and is also the most prevalent lg in secretions (e.g. tears, saliva and mucous).

IgA is resistant to digestion and can activate complement when aggregated. It should also be noted both subclasses of IgA (IgA1 and IgA2) bind fragment crystallization (Fc) receptors.

IgA
Immunoglobulin A

Heavy chain

α

Light chain

κ or λ

Molecular formula

2κ2)n or (α2λ2)n

Valency

2, 4, 6 or 8

Structure

Monomers to tetramers (trimers and tetramers are rare, dimers are more common)

Abundance in serum (in relation to total immunoglobulins present)

13%

Carbohydrate content

10%

Concentration in serum

1.0 - 4.0 mg/ml

IgA subclasses

IgA1

IgA2

Heavy chain subclasses

α1

α2

Heavy chain MW (kDa)

55

55

Light chain MW (kDa)

23

23

Total MW (kDa)

160 (serum monomer)

160 (serum monomer)

600 (secretory tetramer)

600 (secretory tetramer)

Distribution

Intravascular and secretions

Function

Protects mucous membranes


Antibodies for Human IgA Isotype 

Bio-Rad offers a range of human immunoglobulin antibodies for the IgA isotype. In addition to human, we also offer IgA antibodies for the mouse specificity. To find a specific product simply use our search bar at the top of the page.

Human and Mouse IgA Antibodies

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code