GNB1 antibody | AB04/2E5
IP-MS Validated
Mouse anti Human GNB1
- Product Type
- Monoclonal Antibody
- Clone
- AB04/2E5
- Isotype
- IgG2b
- Format
- Purified
- Specificity
- GNB1
Antibody Quality and Performance Guarantee
| Mouse anti Human GNB1 antibody recognizes guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, otherwise known as transducin beta chain 1. GNB1 forms heterotrimeric complexes with G protein subunits α and γ. Mutations in the gene encoding GNB1 result in GNB1 syndrome; with symptoms including developmental delay, hypotonia and epilepsy (Steinrücke et al. 2016). The targeting of GNB1 with microRNA miR-545-3P has been shown to inhibit the progression of some cancers including colon cancer and retinoblastoma (Hu et al. 2022; Tang et al. 2022). Mouse anti Human GNB1 antibody detects a band of 33 kDa. |
|
- Target Species
- Human
- Western Blotting
- Mouse anti Human GNB1 antibody detects a band of 33 kDa in Mouse brain tissue lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 1-340 of human GNB1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/10,000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
- UniProt
- P62873
- Entrez Gene
- GNB1
- GO Terms
- GO:0003924 GTPase activity
- GO:0005834 heterotrimeric G-protein complex
- GO:0004871 signal transducer activity
- GO:0006112 energy reserve metabolic process
- GO:0007213 muscarinic acetylcholine receptor signaling pathway
- GO:0007265 Ras protein signal transduction
- GO:0007268 synaptic transmission
- GO:0030168 platelet activation
- GO:0071377 cellular response to glucagon stimulus
- View More GO Terms
MCA6408GA
100007431
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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