CD57 antibody | rTB01

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Mouse anti Human CD57

Product Type: Monoclonal Antibody
Clone: rTB01
Isotype: IgG1
Specificity: CD57

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16 Formats Available:

Product Code Applications Pack Size List Price Your Price Qty

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TZA1305GA Datasheet SDS SDS	F	0.1 mg		Log in
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Anti Human CD57 Antibody, clone rTB01 thumbnail image 1

Anti Human CD57 Antibody, clone rTB01 thumbnail image 2

Anti Human CD57 Antibody, clone rTB01 thumbnail image 3

Anti Human CD57 Antibody, clone rTB01 thumbnail image 4

Anti Human CD57 Antibody, clone rTB01 thumbnail image 5

Anti Human CD57 Antibody, clone rTB01 thumbnail image 6

Anti Human CD57 Antibody, clone rTB01 thumbnail image 7

Anti Human CD57 Antibody, clone rTB01 thumbnail image 8

Anti Human CD57 Antibody, clone rTB01 gallery image 1 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBV710 (TZA062SBV710) only (Figure A) or with Anti-Human CD56 SBV710 (TZA062SBV710) and Anti-Human CD57 SBUV400 (**TZA1305SBUV400**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 2 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBV515 (TZA062SBV515) only (Figure A) or with Anti-Human CD56 SBV515 (TZA062SBV515) and Anti-Human CD57 SBUV795 (**TZA1305SBUV795**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 3 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBY800 (TZA062SBY800) only (Figure A) or with Anti-Human CD56 SBY800 (TZA062SBY800) and Anti-Human CD57 SBV515 (**TZA1305SBV515**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 4 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBUV400 (TZA062SBUV400) only (Figure A) or with Anti-Human CD56 SBUV400 (TZA062SBUV400) and Anti-Human CD57 SBV610 (**TZA1305SBV610**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 5 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBV515 (TZA062SBV515) only (Figure A) or with Anti-Human CD56 SBV515 (TZA062SBV515) and Anti-Human CD57 SBV790 (**TZA1305SBV790**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 6 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBUV400 (TZA062SBUV400) only (Figure A) or with Anti-Human CD56 SBUV400 (TZA062SBUV400) and Anti-Human CD57 SBB580 (**TZA1305SBB580**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 7 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBV515 (TZA062SBV515) only (Figure A) or with Anti-Human CD56 SBV515 (TZA062SBV515) and Anti-Human CD57 SBB765 (**TZA1305SBB765**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

Anti Human CD57 Antibody, clone rTB01 gallery image 8 — Flow cytometry analysis of human PBMCs stained with Anti-Human CD56 SBV710 (TZA062SBV710) only (Figure A) or with Anti-Human CD56 SBV710 (TZA062SBV710) and Anti-Human CD57 SBY575 (**TZA1305SBY575**) (Figure B). Experiments were performed on PBMCs gated on live, single cell lymphocytes.
Data acquired on the **ZE5 Cell Analyzer**.

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Mouse anti Human CD57 antibody, clone rTB01,is a recombinant monoclonal antibody that recognizes CD57, also known as HNK-1, Leu-7 and NK-1.

CD57 is an oligosaccharide antigenic determinant present on a variety of polypeptides, lipids and chondroitin sulphate proteoglycans. It is expressed on a subset of peripheral blood lymphocytes, including CD8+ T cells and NK cells. The function of CD57 is poorly understood. CD57 binding to laminin and certain selectins suggests it may be involved in cell-cell and cell-matrix interactions.

CD57 is used as a marker for terminally differentiated 'senescent' cells with reduced proliferative capacity and altered functional properties. CD57 expression in CD8+ cells identifies those with reduced proliferative responses to T cell receptor triggering and increased susceptibility to antigen-induced apoptosis. CD57+ T lymphocytes are found at a higher frequency in a variety of diseases. CD57 expression is increased on chronically activated CD8+ T cells in persistent viral infections, such as HIV.

Mouse anti Human CD57, clone rTB01, is derived from clone TB01 (MCA1305), generated by cloning the variable DNA sequences into expression vectors for recombinant protein expression.

Target Species: Human
Product Form: Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
Preparation: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Source: CHO cells
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
Immunogen: Human neuroblastoma cells
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Flow Cytometry

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Flow Cytometry: Use 5μl of the suggested working dilution to label 0.5x10⁶ cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.

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