Calcitonin Receptor antibody | 31/01-1H10-4-1-14

Mouse anti Human Calcitonin Receptor

Product Type
Monoclonal Antibody
Clone
31/01-1H10-4-1-14
Isotype
IgG2a
Specificity
Calcitonin Receptor

Product Code Applications Pack Size List Price Your Price Qty
MCA2191
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E F IF P * WB 0.1 mg loader
List Price Your Price
loader
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Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes the human calcitonin receptor, a membrane protein with seven transmembrane domains that is coupled to G protein messenger systems. Mouse anti Human calcitonin recptor antibody, clone 31/01-1H10-4-1-14 recognizes an epitope within the cytoplasmic domain that is common to both C1a and C1b human isoforms.

Calcitonin receptor is expressed in kidney, central and peripheral nervous systems and on osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rabbit
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
< 0.1% sodium azide (NaN3)
Immunogen
Synthetic peptide, DIPIYICHQELRNEPANN, derived from the cytoplasmic domain of human calcitonin receptor.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised mice were fused with cells of the mouse SP2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/1000 1/5000
Flow Cytometry
Immunofluorescence
Immunohistology - Frozen
Immunohistology - Paraffin 1 1/50 1/500
Western Blotting
  1. 1Fixation with 4% paraformaldehyde is recommended for optimal results.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human kidney

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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)

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Description Mouse IgG2a Negative Control

References for Calcitonin Receptor antibody

  1. Wookey, P.J. et al. (2008) Calcitonin receptor immunoreactivity associated with specific cell types in diseased radial and internal mammary arteries.
    Histopathology. 52 (5): 605-12.
  2. Silvestris, F. et al. (2008) Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro.
    Leuk Res. 32 (4): 611-23.
  3. Wookey, P.J. et al. (2009) The elevated expression of calcitonin receptor by cells recruited into the endothelial layer and neo-intima of atherosclerotic plaque.
    Histochem Cell Biol. 132: 181-9.
  4. Wookey, P.J. et al. (2012) The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172.
    Histopathology. 60 (6): 895-910.
  5. Lesclous, P. et al. (2009) Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?
    Bone. 45 (5): 843-52.
  6. Ostrovskaya, A. et al. (2019) Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas.
    BMC Cancer. 19 (1): 157.
  7. Cappagli, V. et al. (2017) Calcitonin receptor expression in medullary thyroid carcinoma.
    PeerJ. 5: e3778.

UniProt
P30988
Entrez Gene
CALCR
GO Terms
GO:0005515 protein binding
GO:0004948 calcitonin receptor activity
GO:0005887 integral to plasma membrane
GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0032841 calcitonin binding
GO:0045762 positive regulation of adenylate cyclase activity
GO:0051384 response to glucocorticoid stimulus
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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