We offer a wide range of key antibodies for bone and calcium metabolism related research and diseases, including Parathyroid Hormone (PTH), Calcitonin, Osteocalcin.
Parathyroid hormone (PTH), also known as parathormone or parathyrin, is secreted by the parathyroid glands. PTH acts to enhance the release of calcium from bones and increase the blood Ca2+ level, whereas calcitonin (a hormone produced by the thyroid gland) counteracts PTH to lower the calcium concentration.
The unbalanced level of PTH is related to diseases such as hyperparathyroidism, hypoparathyroidism, familial hypocalciuric hypercalcemia, and osteoporosis.
Osteocalcin (BGLAP) is secreted by osteoblasts and plays a role in bone mineralization and calcium ion homeostasis. It is often used as a biomarker to monitor bone formation during the treatment of osteoporosis. Research has also suggested that osteocalcin can be related to male fertility as it may enhance the synthesis of testosterone.