C3aR antibody | 17 (hC3aRZ8)

Mouse anti Human C3aR

Product Type
Monoclonal Antibody
Clone
17 (hC3aRZ8)
Isotype
IgG2b
Specificity
C3aR

Product Code Applications Pack Size List Price Your Price Qty
MCA6160GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F 0.1 mg loader
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loader
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Mouse anti Human C3aR antibody, clone 1hC3aRZ8, recognizes the human receptor of C3a (C3aR), this clone is also known in the literature as clone hC3aRZ8. C3a is a ligand to the seven-transmembrane coupled receptor C3aR. C3aR is expressed in myeloid cells including monocytes, macrophages, dendritic cells as well as T cells, endothelial, epithelial, glial cells and neurons (Wang et al. 2019). The response of C3a binding to C3aR has been shown to be cell type specific. For example, in mast cells, C3a elicits a proinflammatory histamine degranulation response, whereas on neutrophils, C3a exhibits an anti-inflammatory response, through attenuation of neutrophil mobilization into circulation after injury (Mathern & Heeger 2015). Other functionalities have included leukocyte activation, vascular permeability and chemotaxis (Wang et al. 2019). Beyond its immune related functions C3aR has been shown to facilitate osteoclast differentiation and bone formation (Ignatius et al. 2011). It has also been shown to be up-regulated in multiple sclerosis, with increased expression on glial cells (Gasque et al. 1998).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Functional Assays
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)

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Description Mouse IgG2b Negative Control

UniProt
Q16581
Entrez Gene
C3AR1
GO Terms
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004876 complement component C3a receptor activity
GO:0004943 C3a anaphylatoxin receptor activity
GO:0005887 integral to plasma membrane
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0008015 blood circulation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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