C-Reactive Protein antibody | F01-1G4
Mouse anti Human C-Reactive Protein
- Product Type
- Monoclonal Antibody
- Clone
- F01-1G4
- Isotype
- IgG1
- Specificity
- C-Reactive Protein
| Mouse anti Human C-reactive protein antibody, clone F01-1G4 recognizes, C-reactive protein (CRP). CRP is a member of the pentaxin family of proteins which target and activate various stages of the complement system. CRP is known to exist in 2 states, either as a monomer (mCRP) or as a pentamer (pCRP), where the pantamer is composed of 5 nearly identical subunits. The monomeric and pentameric forms have similar functions, but their relative abundance differs across various tissues. For example, pCRP is present in plasma, while mCRP is present mostly in the surface of damaged cells and platelets (Wu et al. 2015). In humans, levels of CRP increases 1,000-fold within 24 to 48 hours of infection, inflammation or tissue damage (Black et al. 2004). In response to infection or tissue damage Interleukin-6, Interleukin-1 beta or glucocorticoids induce hepatocyte production of CRP. Available CRP can then detect foreign invading microorganisms, by binding carbohydrate structures. CRP is also able to bind modified low density lipoproteins and cells undergoing cell death, to assist with phagocytosis and clearance mechanisms. This is directly co-ordinated via CRP and other pentaxin proteins to prevent excessive tissue damage and clearance of any injured tissue components. This purified Mouse anti Human C-reactive protein antibody, clone F01-1G4 (MCA6186GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human C-reactive protein antibody, clone F03-2C7 (MCA6187B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length C-Reactive Protein (Phe17-Pro224)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- ELISA Matched Pair(s)
-
ELISA Matched Pair-Detection Antibody:
MCA6187B
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human C-Reactive Protein:Biotin | MCA6187B | E | 0.1 mg |
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| Description | Mouse anti Human C-Reactive Protein:Biotin | ||||||
- Synonyms
- CRP
- UniProt
- P02741
- Entrez Gene
- CRP
- GO Terms
- GO:0005515 protein binding
- GO:0006953 acute-phase response
- GO:0046872 metal ion binding
- GO:0008228 opsonization
- GO:0010745 negative regulation of macrophage derived foam cell differentiation
- GO:0010888 negative regulation of lipid storage
- GO:0030169 low-density lipoprotein particle binding
- GO:0033265 choline binding
- GO:0051637 Gram-positive bacterial cell surface binding
- View More GO Terms
MCA6186GA
100005432
100008025
64625772
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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