Hematopoietic Stem Cell Markers & Antibodies

Hematopoietic Stem Cells

Hematopoietic stem cells (HSCs) are tissue-specific, multipotent stem cells that give rise to all blood cells. They reside in the bone marrow in a low oxygen environment called the “niche”, where they remain quiescent before eventually dividing and differentiating.

B and T lymphocytes, natural killer cells, dendritic cells, monocytes, platelets, and erythrocytes all originate from hematopoietic stem cells through lineage-specific intermediate progenitors. Hematopoietic stem cells have been extensively used in therapy for certain blood disorders and cancers, and are approved for treatment in humans.

Identifying Hematopoietic Stem Cells

HSCs are a rare cell population, with only around 1 in 2,000 to 1 in 10,000 bone marrow cells HSCs. Popular markers to identify this cell type include: Sca-1, CD27, CD34, CD38, CD43, CD48, CD117 and CD150.

Bio-Rad provides a broad collection of HSCs antibodies. Click on the related links below to explore our product range by marker or use the filters in the table below to sort the attributes in order to find the antibody that fits your exact requirements.

References

• Ng AP and Alexander WS (2017). Haematopoietic stem cells: past, present and future. Cell Death Discovery 3, 17002.
• Challen GA et al. (2009). Mouse Hematopoietic Stem Cell Identification and Analysis. Cytometry A  75, 4-24.
• Clark AD et al. (2003). Isolation and therapeutic potential of human haemopoietic stem cells. Cytotechnology  41, 111-131.