CD31 | Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

CD_31

CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), is a 140 kDa type I integral membrane glycoprotein that is expressed at high levels on early and mature endothelial cells, platelets, and most leukocyte subpopulations.

The expression on endothelial cells is concentrated at junctions between adjacent cells. CD31 is also expressed on a major population of macrophage/dendritic cell precursors in the bone marrow. PECAM-1 is known to have various roles in vascular biology including angiogenesis, platelet function, and thrombosis. It is a mechanosensor of endothelial cell response to fluid shear stress and it is involved in the regulation of leukocyte migration through venular walls.


 


Recent publications with our antibodies

Mouse Anti Human CD31 Clone WM59

  1. Thomas RA et al (2009) Detection and characterization of circulating endothelial progenitor cells in normal rat blood.
    J Pharmacol Toxicol Methods.60(3):263-74

Mouse Anti Rat CD31 Clone TLD-3A12

  1. Kunter U et al (2007) Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes.
    J Am Soc Nephrol 18(6):1754-64