CD105 | Endoglin - Homodimeric Transmembrane Glycoprotein

CD_105CD105 or Endoglin is a Type I homodimeric transmembrane glycoprotein. CD105 is an accessory protein of the transforming growth factor beta receptor complex and it binds TGF beta 1 and 3 with high affinity. Expression of endoglin is elevated on endothelial cells in particular on proliferating cells (healing wounds, developing embryos, inflammatory tissues and solid tumors). CD105 is expressed also on mesenchymal cells. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome a multisystemic vascular dysplasia. CD105 has different isoforms that raise from alternative splicing.

Recent Publications with our Antibodies

Mouse Anti Human CD105 Clone SN6

  1. Tormin A et al (2009) Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets.
    Cytotherapy 11(2):114-28

Mouse Anti Human CD105 Clone SN6 Alexa 647 Conjugated

  1. Roh JD et al (2010) Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling.
    Proc Natl Acad Sci U S A. 107(10):4669-74