CD68 Antibody

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Overview

CD68 is a 110-kDa glycoprotein, being classified as a member of the scavenger receptor family, whose typical functions include clearance of cellular debris, promotion of phagocytosis, and the mediation, recruitment and activation of macrophages. CD68 is also a member of the lysosome associated membrane protein (LAMP) family, where CD68 predominantly localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface.

CD68 is highly expressed by monocytes and tissue macrophages, including Kupffer cells, microglia, histiocytes and osteoclasts, and to a lesser extent on dendritic cells and peripheral blood granulocytes. However CD68 expression is not unique to myeloid cells, it can also be found on hematopoietic and non-hematopoietic cells, and on carcinomas and melanomas especially in tumor stroma cells such as fibroblasts and endothelial cells. CD68 should perhaps be regarded as a phagocytic marker and used alongside other markers to define a cell type.

A CD68 flow cytometry protocol is available that provides detailed procedures for the treatment and staining of this intracellular marker.

CD68 antibodies at a glance

Most popular CD68 antibody options at a glance, click here to view all CD68 antibodies.

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IHC

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References

Anti-rat CD68

• Bao F et al. (2004). Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats.
  J. Neuro-chem. 88:1335-1344.
• Zilka N et al. (2009). Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy.
  J. Neuroimmunol. 209: 16-25.
• Machelska H et al. (2013). Selectins and integrins but not platelet–endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain.
  British Journal of Pharmacology 142:772-780.

Anti-human CD68

• Holness CL and Simmons DL. (1993). Molecular cloning of CD68, human macrophage marker related to lysosomal glycoproteins.
  Blood. 1993 Mar 15;81(6):1607-13.
• Da Costa CE et al. (2005). Presence of osteoclast-like multinucleated giant cells in the bone and nonostoticlesions of Langerhans cell histiocytosis.
  J. Exp Med. 201: 687-93.
• Muthana M et al. (2011). Use of macrophages to target therapeutic adenovirus to human prostate tumors.
  Cancer Res. Jan 13. [Epub ahead of print]

Anti-mouse CD68

• Smith M and Koch G. (1987). Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes.
  J. Cell Sci. 87:113-9.
• Holness CL et al. (1993). Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family.
  J.Biol Chem. 268(13):9661-6.
• Da Silva RP and Gordon S. (1999). Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein.
  Biochem. J. 338: 687-694.

View all anti-CD68 references.