CD68 is a 110-kDa glycoprotein, being classified as a member of the scavenger receptor family, whose typical functions include clearance of cellular debris, promotion of phagocytosis, and the mediation, recruitment and activation of macrophages. CD68 is also a member of the lysosome associated membrane protein (LAMP) family, where CD68 predominantly localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface.
CD68 is highly expressed by monocytes and tissue macrophages, including Kupffer cells, microglia, histiocytes and osteoclasts, and to a lesser extent on dendritic cells and peripheral blood granulocytes. However CD68 expression is not unique to myeloid cells, it can also be found on hematopoietic and non-hematopoietic cells, and on carcinomas and melanomas especially in tumor stroma cells such as fibroblasts and endothelial cells. CD68 should perhaps be regarded as a phagocytic marker and used alongside other markers to define a cell type.
A flow cytometry protocol is available that provides detailed procedures for the treatment and staining of this intracellular marker.
Most popular CD68 antibody options at a glance, click here to view all CD68 antibodies.
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In addition to CD68, Bio-Rad also offers a wide range of other macrophage markers such as:
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