CD200 Receptor 1 antibody | OX-102
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|Mouse anti Rat CD200 Receptor 1 antibody, clone OX-102 recognizes the rat OX2 (CD200) receptor 1. This antigen is a heavily glycosylated ~60-100 kDa cell surface molecule expressed by cells of the myeloid lineage but not by T or B lymphocytes.
Mouse anti Rat CD200 Receptor 1 antibody, clone OX-102 has been shown to block the interaction of OX2 receptor 1 with CD200 (Bushell et al. 2008).
- Target Species
- Product Form
- Purified IgG - liquid
- MCA1959: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- MCA1959GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Membrane fraction of thioglycollate-elicited rat peripheral cells.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the mouse NS1 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
References for CD200 Receptor 1 antibody
Wright, G.J. et al. (2000) Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.
Immunity. 13 (2): 233-42.
Nathan, C. & Muller, W.A. (2001) Putting the brakes on innate immunity: a regulatory role for CD200?
Nat Immunol. 2 (1): 17-9.
Dick, A.D. et al. (2001) Distribution of OX2 antigen and OX2 receptor within retina.
Invest Ophthalmol Vis Sci. 42 (1): 170-6.
Banerjee, D. & Dick, A.D. (2004) Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats.
Ocul Immunol Inflamm. 12 (2): 115-25.
Meuth, S.G. et al. (2008) CNS inflammation and neuronal degeneration is aggravated by impaired CD200-CD200R-mediated macrophage silencing.
J Neuroimmunol. 194 (1-2): 62-9.
Matsumoto, S. et al. (2015) CD200+ and CD200- macrophages accumulated in ischemic lesions of rat brain: the two populations cannot be classified as either M1 or M2 macrophages.
J Neuroimmunol. 282: 7-20.
Chang, J.C. et al. (2019) Early Immune Response to Acute Gastric Fluid Aspiration in a Rat Model of Lung Transplantation.
Exp Clin Transplant. 17 (1): 84-92.
Nicholls, S.M. et al. (2015) Local targeting of the CD200-CD200R axis does not promote corneal graft survival.
Exp Eye Res. 130: 1-8.
View The Latest Product References
Xie, X. et al. (2017) Monocytes, microglia and CD200-CD200R1 signaling are essential in the transmission of inflammation from the periphery to the central nervous system.
J Neurochem. Feb 6. [Epub ahead of print]
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