CD68 antibody

Mouse Fc Receptor Antibodies

CD64 | CD32B | CD16 | CD16-2

Complete range of Mouse Fc Receptor antibodies

Mouse Fc receptors can be classified as either activating (FcRI, FcRIII & FcRIV) or inhibitory (FcRIIB) based on their ability to activate or inhibit cellular processes such as phagocytosis, antigen presentation, the production of reactive oxygen species and cytokines and antibody dependent cell mediated cytotoxicity (ADCC). Macrophages, monocytes, dendritic cells, mast cells and granulocytes express both activating and inhibitory Fc receptors. Recent studies in xeno-transplanted mouse models have suggested that the interaction of Fc receptors with certain therapeutic antibodies (Rituximab & Alemtuzumab) is critical to their function. 


Mouse Fc Receptor antibodies range at a glance

Activating Mouse Fc Receptors

Mouse  Fc Receptor
CD
Clone
Format
Applications
Isotype activation
CD64
AT152-9
Purified, FITC
IHC, Flow Cytometry
IgG2a, IgG2b, IgG3
CD16
AT154-2
Purified, FITC
IHC, Flow Cytometry
IgG1, IgG2a, IgG2b
CD16-2
AT137
Purified, FITC
IHC, Flow Cytometry
IgG2a, IgG2b

Inhibitory Mouse Fc Receptors

Mouse Fc Receptor
CD
Clones
Format
Applications
Isotype activation
CD32B
AT130-5,
Purified, FITC
IHC, Flow Cytometry
IgG1, IgG2a, IgG2b
CD32B
AT130-5R
Purified
IHC
IgG1, IgG2a, IgG2b

Mouse Fc Receptor CD characterization

Mouse Fc Receptor CD characterization

CD64 (FcRI) is a high affinity receptor for monomeric IgG2a and a low affinity receptor for IgG2b and IgG3 type antibodies. IgG binding to FcRI initiates a signaling cascade that involves the common gamma chain and leads to cellular activation. FcRI has been shown to be expressed on monocyte derived dendritic cells.

CD32B (FcRIIB) is a low affinity receptor for IgG1, IgG2a and IgG2b type antibodies. Unlike other Fc Receptors, the intracellular domain of CD32 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that can antagonize signal transduction mediated through other activatory receptors. FcRIIB is expressed on all myeloid populations and on B cells.

CD16 (FcRIII) is a low affinity receptor for IgG1, IgG2a and IgG2b. FcRIII is the only activatory Fc receptor for IgG1. As in other activatory receptors, IgG binding to FcRIII initiates a signaling cascade that involves the common gamma chain and leads to cellular activation. FcRIII is expressed on most myeloid cells including monocytes, macrophages and dendritic cells and also on Natural Killer (NK) and NKT cells.

CD16-2 (FcRIV) is a high affinity receptor for IgG2a and IgG2b type antibodies. FcRIV has no affinity for IgG1 or IgG3 and therefore has unique subclass specificity when compared to other Fc receptors. FcRIV is expressed on monocytes, macrophages and neutrophils.


Fc Receptor References

  • White, A. et al. (2011) Interaction with FcRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.
    J Immunol. 187: 1754-1763.
  • Lunnon, K. et al. (2011) Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration.
    J Immunol. 186: 7215-24.
  • Bruhns P. (2012). Properties of mouse and human IgG receptors and their contribution to disease models.
    Blood. 119(24):5640-9.

 

Mouse Fc Receptor Antibodies

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code