14-3-3 Antibodies

Key mediators of cell signaling pathways

14-3-3 proteins are of key research interest as they regulate many cellular processes and are highly conserved. There are seven mammalian isoforms of 14-3-3; beta, gamma, zeta, epsilon, tau, eta, and sigma, while the alpha and delta isoforms are phosphorylated.

Bio-Rad’s anti-14-3-3 antibodies are part of our wide Cell Signaling antibody range.

eta

tau

Our 14-3-3 Antibody Range

    DescriptionSpecificityTargetFormatHostIsotypeClone Applications Citations Product Type Code

    Western blot

    14-3-3 proteins form dimers that regulate many cellular processes through their interaction with a wide variety of ligands such as

    Research studies suggest that 14-3-3 isoforms are differentially regulated in various diseases, particularly in:

    • Cancer - Expression of 14-3-3 sigma is lost in carcinoma of the breast, ovary, endometrium, prostate, liver, skin and lung.
    • Neurological disorders - 14-3-3 eta forms part of Lewy bodies in Parkinson’s disease and is also linked to early onset schizophrenia. 14-3-3 is also linked to Alzheimer’s disease and prion diseases such as CJD.

    You can complement your 14-3-3 research with reagents from our Oncoprotein and Tumour Suppressor protein, P53 and extensive Neurology antibody ranges.


    References: