TLR7 antibody
Rabbit anti Mouse TLR7 antibody recognizes mouse Toll-like receptor 7 (TLR7). TLR7 is thought to play a role in the innate immune response to viral pathogens.
Mouse TLR7 is localized in endosomal compartments, and recognises single stranded RNA viruses. Stimulation of TLR7 causes a type I IFN response, in a MyD88 dependent pathway.
Mouse TLR7 is localized in endosomal compartments, and recognises single stranded RNA viruses. Stimulation of TLR7 causes a type I IFN response, in a MyD88 dependent pathway.
Product Details
- Target Species
- Mouse
- Species Cross-Reactivity
-
Target Species Cross Reactivity Human - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to was raised by repeated immunization of with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide - Immunogen
- Synthetic peptide corresponding to a 14 amino acid sequence within mouse TLR7.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P58681
- Entrez Gene
- Tlr7
- GO Terms
- GO:0005515 protein binding
- GO:0003725 double-stranded RNA binding
- GO:0003727 single-stranded RNA binding
- GO:0005764 lysosome
- GO:0016021 integral to membrane
- GO:0004888 transmembrane receptor activity
- GO:0005768 endosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0006954 inflammatory response
- GO:0032009 early phagosome
- GO:0032755 positive regulation of interleukin-6 production
- GO:0034154 toll-like receptor 7 signaling pathway
- GO:0035197 siRNA binding
- GO:0045078 positive regulation of interferon-gamma biosynthetic process
- GO:0045087 innate immune response
- GO:0045356 positive regulation of interferon-alpha biosynthetic process
- GO:0045359 positive regulation of interferon-beta biosynthetic process
- GO:0045416 positive regulation of interleukin-8 biosynthetic process
- GO:0051607 defense response to virus
- Regulatory
- For research purposes only
Applications of TLR7 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 0.5ug/ml | 2.0ug/ml |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
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