Papillomavirus 16 Oncoprotein E7 antibody | 716-D1

Mouse anti Human Papillomavirus 16 Oncoprotein E7

Product Type
Monoclonal Antibody
Clone
716-D1
Isotype
IgG2a
Specificity
Papillomavirus 16 Oncoprotein E7

Product Code Applications Pack Size List Price Your Price Qty
MCA2818
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.2 mg loader
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loader
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Mouse anti Human Papillomavirus 16 Oncoprotein E7 antibody, clone 716-D1 recognizes both the monomer and dimer forms of the E7 oncoprotein of human papilloma virus 16. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-supressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection.

Mouse anti Human Papillomavirus 16 Oncoprotein E7 antibody, clone 716-D1 cross-reacts with both the monomer and dimer forms of the E7 protein of HPV-18.

Target Species
Viral
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Oncoprotein E7 from human papillomavirus 16.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Synonyms
HPV
RRID
AB_1102614
UniProt
P03129
Entrez Gene
E7
GO Terms
GO:0005515 protein binding
GO:0005622 intracellular
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
GO:0006355 regulation of transcription, DNA-dependent
GO:0030683 evasion by virus of host immune response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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