Newcastle Disease Virus antibody | 8H2

Mouse anti Newcastle Disease Virus

Product Type
Monoclonal Antibody
Clone
8H2
Isotype
IgG2a
Specificity
Newcastle Disease Virus

Product Code Applications Pack Size List Price Your Price Qty
MCA2822
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.2 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Newcastle Disease Virus antibody, clone 8H2 recognizes the hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV). Newcastle disease is a highly contagious disease affecting wild and domestic birds.

Symptoms of the disease vary greatly, depending on the strain of virus and the species, age and health of the bird. Virulence of the disease can also vary greatly, with some strains causing very high mortality rates. In humans, NDV can cause mild influenza-like symptoms.

The HN protein of the virus is a type II membrane glycoprotein on virion and infected cell surfaces. It binds to sialic acid-containing cellular receptors and promotes activity of the viral fusion protein, thereby allowing the virus to penetrate the cell. It also removes sialic acids from progeny virus particles to prevent viral self-agglutination.

Newcastle disease virus is tumor selective and oncolytic. It has shown promise for selective growth in and killing of a variety of tumor cells.

Target Species
Viral
Product Form
Purified IgG- liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Glycoprotein haemagglutinin-neuraminidase of Newcastle Disease Virus (La-Sota strain).
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Fusion Partners
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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References for Newcastle Disease Virus antibody

  1. Lorence, R.M. et al. (2007) Phase 1 clinical experience using intravenous administration of PV701, an oncolytic Newcastle disease virus.
    Curr Cancer Drug Targets. 7 (2): 157-67.
  2. Huang, Z. et al. (2003) Recombinant Newcastle disease virus as a vaccine vector.
    Poult Sci. 82 (6): 899-906.

Synonyms
NDV
RRID
AB_1102796