CD11b antibody | OX-42
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Mouse anti Rat CD11b
- Product Type
- Monoclonal Antibody
|Product Code||Applications||Pack Size||List Price||Your Price||Qty|
|Mouse anti Rat CD11b, clone OX-42 recognizes rat CD11b, also known as integrin alpha-M, the receptor for the iC3b component of complement. CD11b is a 1151 amino acid single pass type 1 transmembrane glycoprotein posessing a single vWFA domain and multiple FG-GAP repeats. CD11b is expressed on most macrophages, including resident and activated peritoneal macrophages and Kupffer cells and around 35% of alveolar macrophages. The antibody also labels dendritic cells, granulocytes and microglia in the brain (Robinson et al.1986).
Mouse anti Rat CD11b, clone OX-42 is reported to inhibit complement mediated rosettes (Robinson et al.1986) as well as inhibit myelin binding and uptake (van der Laan et al.1996).
- Target Species
- Product Form
- Purified IgG - liquid
- MCA275R: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- MCA275G, MCA275GA: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Resident rat peritoneal macrophages.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the NSO/U mouse myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen||1/50||1/100|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
|Description||Product Code||Applications||Pack Size||List Price||Your Price||Quantity|
|Mouse IgG2a Negative Control||MCA1210||F||100 Tests||Log in|
|List Price||Your Price|
|Description||Mouse IgG2a Negative Control|
References for CD11b antibody
Robinson, A.P. et al. (1986) Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3.
Immunology. 57 (2): 239-47.
Milligan, C.E. et al. (1991) Differential immunochemical markers reveal the normal distribution of brain macrophages and microglia in the developing rat brain.
J Comp Neurol. 314 (1): 125-35.
Yrjanheikki, J. et al. (1999) A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
Proc Natl Acad Sci U S A. 96: 13496-500.
Draskovic-Pavlovic, B. et al. (1999) Differential effects of anti-rat CD11b monoclonal antibodies on granulocyte adhesiveness.
Immunology. 96: 83-9.
Kielian, T. and Hickey, W.F. (2000) Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development.
Am J Pathol. 157: 647-58.
Choi, S.H. et al. (2003) Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.
J Neurosci. 23: 5877-86.
Bruce-Keller, A.J. et al. (2003) Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain.
J Neurosci. 23: 8417-22.
Jin, S.X. et al. (2003) p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.
J Neurosci. 23: 4017-22.
View The Latest Product References
Walczak, P. et al. (2004) Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors?
J Neurosci Res. 76: 244-54.
Stidworthy, M.F. et al. (2004) Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.
Brain, 127: 1928-41.
Foote, A.K. and Blakemore, W.F. (2005) Inflammation stimulates remyelination in areas of chronic demyelination.
Brain. 128: 528-39.
Jha, P. et al. (2006) The complement system plays a critical role in the development of experimental autoimmune anterior uveitis.
Invest Ophthalmol Vis Sci. 47: 1030-8.
Clark, A.K. et al (2007) Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain.
Proc Natl Acad Sci U S A. 104: 10655-60.
Fendrick, S.E. et al. (2007) Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene.
J Neuroinflammation. 4: 9.
Ji, B. et al. (2008) Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
J Neurosci. 28: 12255-67.
Jean, Y.H. et al. (2009) Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats
Br J Pharmacol. 158: 713-25.
Leonardo, C.C. et al. (2009) Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia-ischemia.
Neuroscience. 160: 755-66.
Jin, Y. et al. (2009) Mast cells are early responders after hypoxia-ischemia in immature rat brain.
Stroke. 40: 3107-12.
Baca Jones, C.C. (2009) Rat cytomegalovirus infection depletes MHC II in bone marrow derived dendritic cells.
Virology. 388: 78-90.
Schlichter, L.C. et al. (2010) The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro.
J Neuroinflammation. 7: 4.
Pickard, M.R. and Chari, D.M. (2010) Robust uptake of magnetic nanoparticles (MNPs) by central nervous system (CNS) microglia: Implications for particle uptake in mixed neural cell populations.
Int J Mol Sci. 11: 967-81.
Medders, K.E. et al. (2010) Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity.
J Immunol. 185: 4883-95.
Li, K. et al. (2010) Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception.
J Neuroimmunol. 221: 25-31.
Su, D. et al. (2010) Lidocaine attenuates proinflammatory cytokine production induced by extracellular adenosine triphosphate in cultured rat microglia.
Anesth Analg. 111: 768-74.
Jokic, N. et al. (2010) The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression.
BMC Genomics. 11: 633.
Zhou, D. et al. (2010) Involvement of spinal microglial P2X7 receptor in generation of tolerance to morphine analgesia in rats.
J Neurosci. 30: 8042-7.
Smith, J.S. et al. (2010) Role of Early Surgical Decompression of the Intradural Space After Cervical Spinal Cord Injury in an Animal Model
J Bone Joint Surg Am. 92: 1206-14.
Jiang, Y. et al. (2010) Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat.
Mediators Inflamm. 2010: 372423.
Graber, D.J. et al. (2010) Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis.
J Neuroinflammation. 7: 8.
Jeong, H.K. et al. (2010) Inflammatory responses are not sufficient to cause delayed neuronal death in ATP-induced acute brain injury.
PLoS One. 5: e13756.
Wu, J. et al. (2010) Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord.
Glia. 58: 410-22.
Guo, W. et al. (2010) Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain.
Mol Pain. 6: 40.
Shokouhi, B.N. et al (2010) Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration.
BMC Neurosci. 11: 13.
Calvo, M. et al. (2010) Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury.
J Neurosci. 30 (15): 5437-50.
Chew, S.S. et al. (2011) Response of retinal Connexin43 to optic nerve injury.
Invest Ophthalmol Vis Sci. 52: 3620-9.
Spencer-Segal, J.L. et al. (2011) Distribution of Phosphorylated TrkB Receptor in the Mouse Hippocampal Formation Depends on Sex and Estrous Cycle Stage.
J Neurosci. 31: 6780-90.
Converse, A.K. et al. (2011) 11C-(R)-PK11195 PET imaging of microglial activation and response to minocycline in zymosan-treated rats.
J Nucl Med. 52: 257-62.
Feng, Y. et al (2011) Gene expression profiling of vasoregression in the retina--involvement of microglial cells.
PLoS One. 6(2): e16865.
Szmydynger-Chodobska, J. et al. (2011) Multiple sites of vasopressin synthesis in the injured brain.
J Cereb Blood Flow Metab. 31: 47-51.
Toda, S. et al. (2011) A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain.
Mol Pain. 7: 2.
Xu, Q. et al. (2011) Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
J Neurosci. 31: 2113-24.
Morales-Garcia, J.A. et al. (2011) Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.
PLoS One. 6(2):e17240.
Signarovitz, A.L. et al. (2012) Mucosal immunization with live attenuated Francisella novicida U112ΔiglB protects against pulmonary F. tularensis SCHU S4 in the Fischer 344 rat model.
PLoS One. 7: e47639.
Ortega, F.J. et al. (2012) Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia.
J Cereb Blood Flow Metab. 33: 356-64.
Lavisse, S. et al. (2012) Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.
J Neurosci. 32: 10809-18.
Schonberg, D.L. et al. (2012) Ferritin stimulates oligodendrocyte genesis in the adult spinal cord and can be transferred from macrophages to NG2 cells in vivo.
J Neurosci. 32: 5374-84.
d'Avila, J.C. et al. (2012) Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor.
J Neuroinflammation. 9: 31.
Lovett-Barr, M.R. et al. (2012) Repetitive intermittent hypoxia induces respiratory and somatic motor recovery after chronic cervical spinal injury.
J Neurosci. 32 (11): 3591-600.
Tchoukalova, Y.D. et al. (2012) In vivo adipogenesis in rats measured by cell kinetics in adipocytes and plastic-adherent stroma-vascular cells in response to high-fat diet and thiazolidinedione.
Diabetes. 61: 137-44.
Zhang, Z.J. et al. (2012) Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain.
J Neuroinflammation. 9: 136.
Liew, H.K. et al. (2012) Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats.
J Neuroinflammation. 9: 13.
de Sousa, É et al. (2013) Developmental and functional expression of miRNA-stability related genes in the nervous system.
PLoS One. 8 (5): e56908.
Zhao, H. et al. (2013) Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke.
PLoS One. 8(6):e67322.
Huang, S. et al. (2015) Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats.
Cell Mol Neurobiol. 35 (8): 1217-26.
Hernangómez M et al. (2016) CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model.
J Neuroinflammation. 13 (1): 43.
Szmydynger-Chodobska, J. et al. (2016) The Involvement of Pial Microvessels in Leukocyte Invasion after Mild Traumatic Brain Injury.
PLoS One. 11 (12): e0167677.
Liu, Z. et al. (2016) Leukocyte Infiltration Triggers Seizure Recurrence in a Rat Model of Temporal Lobe Epilepsy.
Inflammation. 39 (3): 1090-8.
Chen, X. et al. (2017) TGF-β1 Neuroprotection via Inhibition of Microglial Activation in a Rat Model of Parkinson's Disease.
J Neuroimmune Pharmacol. 12 (3): 433-46.
Popiolek-Barczyk, K. et al. (2017) Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.
Neural Plast. 2017: 3829472.
Huang RY et al. (2017) Rapid and Delayed Effects of Pulsed Radiofrequency on Neuropathic Pain: Electrophysiological, Molecular, and Behavioral Evidence Supporting Long-Term Depression.
Pain Physician. 20 (2): E269-E283.
Chong, S.A. et al. (2018) Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model.
Neurotherapeutics. 15 (2): 470-88.
Terayama, R. et al. (2018) A3 adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn.
Exp Brain Res. 236 (12): 3203-13.
Sanches, E.F. et al. (2018) Brain Metabolism Alterations Induced by Pregnancy Swimming Decreases Neurological Impairments Following Neonatal Hypoxia-Ischemia in Very Immature Rats.
Front Neurol. 9: 480.
Collins, J.J.P. et al. (2018) Impaired Angiogenic Supportive Capacity and Altered Gene Expression Profile of Resident CD146+ Mesenchymal Stromal Cells Isolated from Hyperoxia-Injured Neonatal Rat Lungs.
Stem Cells Dev. 27 (16): 1109-24.
Wang, Z.C. et al. (2018) Involvement of NF-κB and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation.
Neurosci Bull. 34 (1): 64-73.
Bourke, G. et al. (2018) Effects of early nerve repair on experimental brachial plexus injury in neonatal rats.
J Hand Surg Eur Vol. 43 (3): 275-81.
Yuan, Z. et al. (2019) The anti-inflammatory effect of minocycline on endotoxin-induced uveitis and retinal inflammation in rats.
Mol Vis. 25: 359-72.
Hansson, E. & Skiöldebrand, E. (2019) Anti-inflammatory effects induced by ultralow concentrations of bupivacaine in combination with ultralow concentrations of sildenafil (Viagra) and vitamin D3 on inflammatory reactive brain astrocytes.
PLoS One. 14 (10): e0223648.
Muratori, L. et al. (2019) New basic insights on the potential of a chitosan-based medical device for improving functional recovery after radical prostatectomy.
BJU Int. 124 (6): 1063-76.
Hahm, S.C. et al. (2019) Transcutaneous Electrical Nerve Stimulation Reduces Knee Osteoarthritic Pain by Inhibiting Spinal Glial Cells in Rats.
Phys Ther. 99 (9): 1211-23.
Hellenbrand, D.J. et al. (2019) Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury.
J Neuroinflammation. 16 (1): 93.
Sugama, S. et al. (2019) Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation.
J Neuroinflammation. 16 (1): 266.
Anqi, X. et al. (2019) Neuroprotective potential of GDF11 in experimental intracerebral hemorrhage in elderly rats.
J Clin Neurosci. 63: 182-8.
Klemm, P. et al. (2019) Hypothermia protects retinal ganglion cells against hypoxia-induced cell death in a retina organ culture model.
Clin Exp Ophthalmol. 47 (8): 1043-54.
Allendorf, D.H. et al. (2020) Activated microglia desialylate their surface, stimulating complement receptor 3-mediated phagocytosis of neurons.
Glia. 68 (5): 989-998.
Cohrs, G. et al. (2020) Expression Patterns of Hypoxia-Inducible Factors, Proinflammatory, and Neuroprotective Cytokines in Neuroepithelial Tissues of Lumbar Spinal Lipomas-A Pilot Study.
World Neurosurg. 141: e633-e644.
Lin, J. et al. (2020) Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease.
Theranostics. 10 (17): 7857-71.
Memedovski, Z. et al. (2020) Classical and Alternative Activation of Rat Microglia Treated with Ultrapure Porphyromonas gingivalis Lipopolysaccharide In Vitro..
Toxins (Basel). 12(5): 333.
Espinosa-Garcia, C. et al. (2020) Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.
Int J Mol Sci. 21 (11): 3740.
Tanaka, J. et al. (2020) Generation of CSF1-Independent Ramified Microglia-Like Cells from Leptomeninges In Vitro.
Cells. 10 (1)Dec 25 [Epub ahead of print].
van Vliet, E.A. (2020) Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury
Neurobiol Dis 11:13.
Mecha, M. et al. (2020) Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis.
J Neuroinflammation. 17 (1): 88.
Chun, S. et al. (2021) The Peripheral Role of CCL2 in the Anti-Nociceptive Effect of Sigma-1 Receptor Antagonist BD1047 on Inflammatory Hyperalgesia in Rats.
Int J Mol Sci. 22(21):11730.
Elabi, O.F. et al. (2021) L-dopa-Dependent Effects of GLP-1R Agonists on the Survival of Dopaminergic Cells Transplanted into a Rat Model of Parkinson Disease.
Int J Mol Sci. 22(22):12346.
Zhang, J. et al. (2021) Significant higher-level C-C motif chemokine ligand 2/3 and chemotactic power in cerebral white matter than grey matter in rat and human.
Eur J Neurosci. Mar 16 [Epub ahead of print].
Sato, T. et al. (2021) Distribution of alpha-synuclein in the rat cranial sensory ganglia, and oro-cervical regions.
Ann Anat. 238: 151776.
Winkler, A. et al. (2021) Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration.
J Clin Invest. 131(5):e141694.
Schnichels, S. et al. (2021) Cyclosporine A Protects Retinal Explants against Hypoxia.
Int J Mol Sci. 22 (19):10196.
Valenzuela, R. et al. (2021) An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria.
Redox Biol. 46: 102078.
Giuliano, C. et al. (2021) Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease.
Int J Mol Sci. 22 (16): 8920.
Hosoi, R. et al. (2021) Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity.
EJNMMI Res. 11 (1): 99.
Szeredi, I.D. et al. (2021) Prior perineural or neonatal treatment with capsaicin does not alter the development of spinal microgliosis induced by peripheral nerve injury.
Cell Tissue Res. 383 (2): 677-92.
Kuo, T.T. et al. (2021) Post-stroke Delivery of Valproic Acid Promotes Functional Recovery and Differentially Modifies Responses of Peri-Infarct Microglia.
Front Mol Neurosci. 14: 639145.
Joya, A. et al. (2021) In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke.
Theranostics. 11 (1): 410-25.
Lane, E.L. et al. (2022) Spontaneous Graft-Induced Dyskinesias Are Independent of 5-HT Neurons and Levodopa Priming in a Model of Parkinson's Disease.
Mov Disord. 37 (3): 613-9.
Kuter, K.Z. et al. (2022) The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.
Pharmacol Rep. 74 (1): 67-83.
Huang, S. et al. (2022) Hydrogen sulfide supplement preserves mitochondrial function of retinal ganglion cell in a rat glaucoma model.
Cell Tissue Res. 389 (2): 171-85.
Dias, L. et al. (2022) Aβ1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes.
Cell Mol Life Sci. 79 (8): 457.
Andrioli, A. et al. (2022) Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus.
Int J Mol Sci. 24 (1): 23.
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