Vwf antibody | C01-1F2
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E ResetMouse anti Human Vwf
- Product Type
- Monoclonal Antibody
- Clone
- C01-1F2
- Isotype
- IgG1
- Specificity
- Vwf
Antibody Quality and Performance Guarantee
| Mouse anti Human vWF antibody, clone C01-1F2, recognizes von Willebrand factor (vWF) a multifunctional glycoprotein that plays essential roles in primary and secondary homeostasis, mediates platelet adhesion and is a carrier of coagulation factor VIII (Yasar et al. 2018). vWF is present in blood plasma, the subendothelial matrix, platelet granules (α granules) and endothelial cells (Kawecki et al. 2017). In endothelial cells, the vWF is stored in mature Weibel-Palade bodies before it is secreted into the plasma (Yasar et al. 2018). vWF plasma levels are influenced by genetic, pathological, hormonal and environmental interactions (Swystun & Lillicrap 2018). Upon vascular injury, vWF mediates the anchoring of platelets to the subendothelium leading to the formation of a platelet plug and the arrest of bleeding. Due to its acute release by the activated epithelium, vWF has been considered a marker of inflammation in various pathologies. However there is evidence that vWF is able to play a direct role in inflammation by recruiting leukokcytes to sites of inflammation (Kawecki et al. 2017). The purified Mouse anti Human vWF antibody, clone C01-1F2 (MCA6288GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human vWF antibody, clone E01-1C8 (MCA6289B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- CHO derived recombinant full length human vWF (Met1-Lys2813)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human Vwf:Biotin | MCA6289B | E | 0.1 mg |
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| Description | Mouse anti Human Vwf:Biotin | ||||||
- UniProt
- P04275
- Entrez Gene
- VWF
- GO Terms
- GO:0001948 glycoprotein binding
- GO:0002020 protease binding
- GO:0002576 platelet degranulation
- GO:0051087 chaperone binding
- GO:0005783 endoplasmic reticulum
- GO:0005178 integrin binding
- GO:0005518 collagen binding
- GO:0005578 proteinaceous extracellular matrix
- GO:0007597 blood coagulation, intrinsic pathway
- View More GO Terms
- GO:0019865 immunoglobulin binding
- GO:0030168 platelet activation
- GO:0031093 platelet alpha granule lumen
- GO:0031589 cell-substrate adhesion
- GO:0033093 Weibel-Palade body
- GO:0042803 protein homodimerization activity
- GO:0051260 protein homooligomerization
- GO:0047485 protein N-terminus binding
MCA6288GA
100005325
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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