TCR Gamma/Delta antibody | B1


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F ResetMouse anti Human TCR Gamma/Delta
- Product Type
- Monoclonal Antibody
- Clone
- B1
- Isotype
- IgG1
- Specificity
- TCR Gamma/Delta
Mouse anti Human TCR gamma/delta, clone B1 recognizes TCR gamma/delta, a T cell receptor expressed by a small subset of T cells. In healthy individuals these TCR gamma/delta cells account for 1-10% of peripheral blood lymphocytes (Gomes et al. 2010). TCR gamma/delta is composed of disulfide bonded gamma and delta chains that can bind directly to pathogen derived glycoprotein's or non-classical MHC molecules on tumor cells (Kuhns et al. 2006). This clone B1 has been used as a blocking antibody in experiments to examine the recognition of tumor cells by TCR gamma/delta cells. These experiments supported the hypothesis that innate NK receptors on gamma/delta cells can also bind and recognize tumor cells (Correia et al. 2011). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Primate - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Purity
- >95% by SDS PAGE
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
This product should be stored undiluted.
Application Name | Verified | Min Dilution | Max Dilution |
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Flow Cytometry | ![]() |
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Immunohistology - Frozen | ![]() |
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Immunohistology - Paraffin | ![]() |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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Description | Mouse IgG1 Negative Control |
References for TCR Gamma/Delta antibody
-
Correia, D.V. et al. (2011) Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.
Blood. 118 (4): 992-1001. -
Kuhns, M.S. et al. (2006) Deconstructing the form and function of the TCR/CD3 complex.
Immunity. 24 (2): 133-9. -
Gomes, A.Q. et al. (2010) Targeting γδ T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application.
Cancer Res. 70 (24): 10024-7.
- UniProt
- P07766
- Entrez Gene
- CD3E
- GO Terms
- GO:0004888 transmembrane receptor activity
- GO:0005057 receptor signaling protein activity
- GO:0005887 integral to plasma membrane
- GO:0007172 signal complex assembly
- GO:0007186 G-protein coupled receptor protein signaling pathway
- GO:0009897 external side of plasma membrane
- GO:0017124 SH3 domain binding
- GO:0019901 protein kinase binding
- GO:0030159 receptor signaling complex scaffold activity
- View More GO Terms
- GO:0031295 T cell costimulation
- GO:0042608 T cell receptor binding
- GO:0046982 protein heterodimerization activity
- GO:0050852 T cell receptor signaling pathway
MCA6139


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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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