SOS1 antibody | SOS-01
Mouse anti SOS1
- Product Type
- Monoclonal Antibody
- Clone
- SOS-01
- Isotype
- IgG1
- Specificity
- SOS1
Antibody Quality and Performance Guarantee
| Mouse anti Human SOS1 antibody, clone SOS-01 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150 kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hart et al. 2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hanna et al. 2009). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human SOS1.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Immunofluorescence | |
||
| Western Blotting | |
1.0ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- MCA2887 detects a band of approximately 150kDa in K562 and RAJI human cell lysates under reducing conditions.
Further Reading
-
Scita, G. et al. (2000) Signaling from Ras to Rac and beyond: not just a matter of GEFs.
EMBO J. 19 (11): 2393-8.
- Synonyms
- Son Of Sevenless Homolog 1
- RRID
- AB_2192440
- UniProt
- Q07889
- Entrez Gene
- SOS1
- GO Terms
- GO:0005515 protein binding
- GO:0003677 DNA binding
- GO:0007596 blood coagulation
- GO:0006915 apoptosis
- GO:0005829 cytosol
- GO:0005089 Rho guanyl-nucleotide exchange factor activity
- GO:0005100 Rho GTPase activator activity
- GO:0007173 epidermal growth factor receptor signaling pathway
- GO:0007265 Ras protein signal transduction
- View More GO Terms
- GO:0007411 axon guidance
- GO:0008286 insulin receptor signaling pathway
- GO:0008543 fibroblast growth factor receptor signaling pathway
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0035023 regulation of Rho protein signal transduction
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050900 leukocyte migration
MCA2887
161243
241013
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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